Reiner T, Pfleiderer W
Fakultät für Chemie, Universität Konstanz, FRG.
Nucleic Acids Symp Ser. 1987(18):161-4.
Three beta-substituted ethylsulfonyl chlorides 1-3 were synthesized and their usefulness as 5'-OH protecting groups for oligonucleotide synthesis studied. The formation of the corresponding 5'-beta-R-ethyl-sulfonic acid esters was investigated in respect to fast and complete capping. The 5'-sulfonates 4-9 were prepared and the deprotection was studied using reversed phase HPLC as the analytical tool.
合成了三种β-取代的乙基磺酰氯1-3，并研究了它们作为寡核苷酸合成中5'-OH保护基团的实用性。针对快速且完全的封端，研究了相应的5'-β-R-乙基磺酸酯的形成。制备了5'-磺酸盐4-9，并使用反相高效液相色谱作为分析工具研究了脱保护。
