Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, U.S.A.
Laryngoscope. 2023 Dec;133(12):3279-3284. doi: 10.1002/lary.30662. Epub 2023 Mar 27.
To determine the impact of comorbid migraine on quality of life (QOL) in chronic rhinosinusitis (CRS).
A total of 213 adult patients with CRS were recruited. All participants completed the 22-item Sinonasal Outcome Test (SNOT-22), from which total and validated nasal, ear/facial pain, sleep, and emotional subdomain scores were calculated, and the 5-dimension EuroQol general health questionnaire (EQ-5D), from which the visual analogue scale (VAS) and health utility value (HUV) were calculated. The presence of comorbid migraine was determined by a score of ≥4 on the 5-item Migraine Screen Questionnaire (MS-Q).
Of the participants, 36.2% were screened positive for having comorbid migraine. The mean SNOT-22 score was 64.9 (SD: 18.7) in participants with migraine and 41.5 (SD: 21.1) in participants without migraine (p < 0.001). The mean EQ-5D VAS and HUV were 60.2 (SD: 21.9) and 0.69 (SD: 0.18), respectively, in participants with migraine and 71.4 (SD: 19.4) and 0.84 (SD: 0.13), respectively, in participants without migraine (p < 0.001 for both). Higher ear/facial pain (OR = 1.22, 95% CI: 1.10-1.36, p < 0.001) and sleep (OR = 1.11, 95% CI: 1.04-1.18, p = 0.002) SNOT-22 subdomain scores were positively associated with migraine. The SNOT-22 item scores related to dizziness, reduced concentration, and facial pain, in descending order, were most associated with migraine. The presence of nasal polyps (OR = 0.24, 95% CI: 0.07 - 0.80, p = 0.020) was negatively associated with migraine.
Comorbid migraine may be relatively common amongst CRS patients, and its presence is associated with significantly worse QOL. Dizziness as a symptom in CRS patients may be particularly indicative of migraine.
3 Laryngoscope, 133:3279-3284, 2023.
确定合并偏头痛对慢性鼻-鼻窦炎（CRS）患者生活质量（QOL）的影响。
共招募了 213 名成年 CRS 患者。所有参与者均完成了 22 项鼻-鼻窦结局测试（SNOT-22），并计算了总分和经验证的鼻腔、耳部/面部疼痛、睡眠和情绪子域评分，以及 5 维欧洲五维健康量表（EQ-5D），并计算了视觉模拟量表（VAS）和健康效用值（HUV）。通过偏头痛筛查问卷（MS-Q）的 5 项得分≥4 来确定合并偏头痛的存在。
参与者中，36.2%的人被筛查出合并偏头痛。偏头痛患者的 SNOT-22 评分为 64.9（SD：18.7），无偏头痛患者为 41.5（SD：21.1）（p<0.001）。偏头痛患者的 EQ-5D VAS 和 HUV 分别为 60.2（SD：21.9）和 0.69（SD：0.18），无偏头痛患者分别为 71.4（SD：19.4）和 0.84（SD：0.13）（均 p<0.001）。耳部/面部疼痛（OR=1.22，95%CI：1.10-1.36，p<0.001）和睡眠（OR=1.11，95%CI：1.04-1.18，p=0.002）SNOT-22 子域评分与偏头痛呈正相关。与偏头痛最相关的 SNOT-22 项目评分依次为头晕、注意力不集中和面部疼痛。存在鼻息肉（OR=0.24，95%CI：0.07-0.80，p=0.020）与偏头痛呈负相关。
合并偏头痛在 CRS 患者中可能较为常见，其存在与生活质量显著下降相关。CRS 患者的头晕症状可能特别提示偏头痛。
3 Laryngoscope, 133:3279-3284, 2023.
