疾病中的睡眠：炎症与慢性鼻窦炎
Sleep in disease: inflammation and chronic rhinosinusitis.
作者信息
Pandrangi Vivek C, Alt Jeremiah A
机构信息
Oregon Health & Science University, Department of Otolaryngology-Head and Neck Surgery, Portland, OR, USA.
University of Utah, Department of Otolaryngology-Head and Neck Surgery, Salt Lake City, UT, USA.
出版信息
Neurobiol Sleep Circadian Rhythms. 2025 Apr 26;18(Suppl):100120. doi: 10.1016/j.nbscr.2025.100120. eCollection 2025 May.
Chronic rhinosinusitis (CRS) is a common inflammatory disorder that is associated with significant quality of life (QOL) impairment, including sleep dysfunction. There are multiple factors that have been independently associated with poor sleep among this population including alterations in inflammatory mediators, rhinologic symptom interference such as nasal discharge, obstruction, and facial pain, and co-morbid conditions including asthma. While there is a high prevalence of sleep dysfunction among this population, treatment with both medical and surgical options may lead to sustained improvements in sleep. This review aims to highlight the burden of sleep dysfunction, discuss common theories regarding the etiology, and evaluate strategies that may facilitate improvement in sleep dysfunction among patients with CRS.
慢性鼻-鼻窦炎（CRS）是一种常见的炎症性疾病，与包括睡眠功能障碍在内的显著生活质量（QOL）受损相关。在这一人群中，有多种因素与睡眠不佳独立相关，包括炎症介质的改变、鼻科症状干扰，如流涕、鼻塞和面部疼痛，以及包括哮喘在内的共病情况。虽然这一人群中睡眠功能障碍的患病率很高，但药物和手术治疗都可能使睡眠得到持续改善。本综述旨在强调睡眠功能障碍的负担，讨论关于病因的常见理论，并评估可能有助于改善CRS患者睡眠功能障碍的策略。
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