Dvoráková H, Holý A
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha.
Nucleic Acids Symp Ser. 1987(18):29-32.
Fluorescent analogs of S-adenosyl-L-homocysteinase inhibitors derived from acyclic nucleoside series have been synthetized by alkylation of heterocyclic bases with appropriate synthons, or by modification of preformed adenine derivatives. None of the newly prepared compounds derived from 2-aminopurine, lin-benzoadenine or 1,6-ethenoadenine significantly inhibited the above enzyme.
通过用合适的合成子对杂环碱基进行烷基化，或通过对预先形成的腺嘌呤衍生物进行修饰，合成了无环核苷系列的S-腺苷-L-同型半胱氨酸酶抑制剂的荧光类似物。从2-氨基嘌呤、林-苯并腺嘌呤或1,6-乙烯基腺嘌呤衍生而来的新制备化合物均未显著抑制上述酶。
