Division of Cancer Epidemiology and Genetics, NCI, NIH, Rockville, Maryland.
Leidos Biomedical Research, Inc., National Laboratory for Cancer Research, Frederick, Maryland.
Cancer Res. 2023 Jun 2;83(11):1768-1781. doi: 10.1158/0008-5472.CAN-22-3030.
Multimers of the HPV genome are generated in cervical tumors replicating as extrachromosomal episomes, which is associated with deletion and rearrangement of the HPV genome and provides a mechanism for oncogenesis without integration.
HPV 基因组的多聚体在作为染色体外附加体复制的宫颈肿瘤中产生,这与 HPV 基因组的缺失和重排有关,并提供了一种不整合即可致癌的机制。