通过肌肉注射给予气喘鹤（）的头孢噻呋无定形酸的药代动力学。

PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE-FREE ACID ADMINISTERED VIA INTRAMUSCULAR INJECTION IN WHOOPING CRANES ().

机构信息

International Crane Foundation, Baraboo, WI 53913, USA, and the School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA,

University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996, USA.

出版信息

J Zoo Wildl Med. 2023 Mar;54(1):1-7. doi: 10.1638/2022-0058.

DOI:10.1638/2022-0058

PMID:36971622

Abstract

The objective of this study was to evaluate the pharmacokinetic properties of a single dose of ceftiofur crystalline-free acid (CCFA) in whooping cranes (). Ceftiofur crystalline-free acid is a long-acting, injectable, third-generation cephalosporin antibiotic drug. A preliminary study evaluated CCFA administered intramuscularly in the pectoral or thigh muscle at 20 or 30 mg/kg IM to a single adult whooping crane for each dose. On the basis of these data, a dose of 30 mg/kg IM of CCFA was administered to five additional whooping cranes, and blood was collected at various time points from 0 to 288 h. Pharmacokinetic parameters for ceftiofur equivalents were determined and reached concentrations above minimum inhibitory concentrations of various bacteria in other avian species (>1 µg/ml) for at least 96 h in all birds, and for 144 h in two birds. From these findings, ceftiofur crystalline-free acid appears to be a long-acting antibiotic option for whooping cranes and may be dosed every 96 h; however, additional multidose studies are needed.

摘要

本研究旨在评估单次剂量头孢噻呋游离酸（CCFA）在美洲鹤（）中的药代动力学特性。头孢噻呋游离酸是一种长效、可注射的第三代头孢菌素抗生素药物。一项初步研究评估了每只成年美洲鹤肌肉内注射 20 或 30mg/kg 的 CCFA，分别在胸肌或大腿肌肉中进行。基于这些数据，对另外五只美洲鹤给予 30mg/kg 的 CCFA 肌肉内注射，从 0 到 288 小时收集各种时间点的血液。确定了头孢噻呋等效物的药代动力学参数，所有鸟类的浓度至少在 96 小时内均高于其他禽类物种各种细菌的最低抑菌浓度（>1µg/ml），在两只鸟类中为 144 小时。根据这些发现，头孢噻呋游离酸似乎是一种长效抗生素选择，可用于美洲鹤，每 96 小时给药一次；但是，还需要进行更多的多剂量研究。