Zheng Jiachen, Xu Min, Xu Haoyue, Ye Fei, Liu Xiaozhou, Liu Yumin, Jin Xiaoqing
Emergency Center, Zhongnan Hospital of Wuhan University, No. 169, Donghu Road, Wuchang District, Wuhan, 430071, Hubei, China.
Hubei Clinical Research Center for Emergency and Resuscitation, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Environ Sci Pollut Res Int. 2023 Apr;30(20):57707-57716. doi: 10.1007/s11356-023-26575-4. Epub 2023 Mar 27.
This study aimed to disclose the relationship between ambient air pollution and neurology clinic visits (NCVs) for vertigo. A time-series study was conducted to examine relationships between six different criteria air pollutants (SO, NO, PM, PM, CO, and O) and daily NCVs for vertigo in Wuhan, China, from January 1st, 2017 to November 30th, 2019. Stratified analyses were computed according to gender, age, and season. A total of 14,749 records of NCVs for vertigo were enrolled in this study. Data showed that the increase in daily NCVs for vertigo corresponding to 10 μg/m increase of respective pollutants are: SO (- 7.60%; 95% CI: - 14.25 to - 0.44%), NO (3.14%; 95% CI: 0.23 to 6.13%), PM (0.53%; 95% CI: - 0.66 to 1.74%), PM (1.32%; 95% CI: - 0.36 to 3.06%), CO (0.00%; 95% CI: - 0.12 to 0.13%), and O (0.90%; 95% CI: - 0.01% to 1.83%). Males were more susceptible to acute exposure to SO and NO, compared to females (SO: - 11.91% vs. - 4.16%; NO: 3.95% vs. 2.92%), whereas the acute effect of O exposure was more significantly obvious in females than males (0.94% vs. 0.87%). Moreover, correlations between daily NCVs for vertigo and acute exposure to SO, NO, and O were all stronger in individuals under 50 years old (SO: - 12.75% vs. - 4.41%; NO: 4.55% vs. 2.75%; O: 1.27% vs. 0.70%). Short-term exposure to PM was more significantly associated with daily NCVs for vertigo in cool seasons (1.62% vs. - 0.68%), while the correlation between CO exposure and daily NCVs for vertigo was stronger in warm seasons (0.21% vs. - 0.03%). Our study demonstrated acute exposure to ambient NO and O positively associated with daily NCVs for vertigo. Acute effects of air pollution on daily NCVs for vertigo varied according to gender, age, and season.
本研究旨在揭示环境空气污染与眩晕的神经内科门诊就诊量（NCVs）之间的关系。开展了一项时间序列研究，以考察中国武汉2017年1月1日至2019年11月30日期间六种不同的环境空气质量标准污染物（二氧化硫、二氧化氮、细颗粒物、可吸入颗粒物、一氧化碳和臭氧）与每日眩晕NCVs之间的关系。根据性别、年龄和季节进行分层分析。本研究共纳入了14749条眩晕NCVs记录。数据显示，各污染物每增加10μg/m³，每日眩晕NCVs相应的增加幅度为：二氧化硫（-7.60%；95%置信区间：-14.25%至-0.44%）、二氧化氮（3.14%；95%置信区间：0.23%至6.13%）、细颗粒物（0.53%；95%置信区间：-0.66%至1.74%）、可吸入颗粒物（1.32%；95%置信区间：-0.36%至3.06%）、一氧化碳（0.00%；95%置信区间：-0.12%至0.13%）和臭氧（0.90%；95%置信区间：-0.01%至1.83%）。与女性相比，男性对二氧化硫和二氧化氮的急性暴露更敏感（二氧化硫：-11.91%对-4.16%；二氧化氮：3.95%对2.92%），而臭氧暴露对女性的急性影响比男性更明显（0.94%对0.87%）。此外，50岁以下个体中，每日眩晕NCVs与二氧化硫、二氧化氮和臭氧急性暴露之间的相关性更强（二氧化硫：-12.75%对-4.41%；二氧化氮：4.55%对2.75%；臭氧：1.27%对0.70%）。在凉爽季节，短期暴露于可吸入颗粒物与每日眩晕NCVs的相关性更显著（1.62%对-0.68%），而在温暖季节，一氧化碳暴露与每日眩晕NCVs的相关性更强（0.21%对-0.03%）。我们的研究表明，环境二氧化氮和臭氧的急性暴露与每日眩晕NCVs呈正相关。空气污染对每日眩晕NCVs的急性影响因性别、年龄和季节而异。
