The Emergency Center, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei, China.
The Second Clinical School of Wuhan University, Wuhan, 430071, Hubei, China.
BMC Public Health. 2023 May 5;23(1):828. doi: 10.1186/s12889-023-15770-0.
Previous studies showed the adverse impacts of air pollution on headache attacks in developed countries. However, evidence is limited to the impact of exposure to air pollutants on headache attacks. In this study, we aimed to explore the impact of nitrogen dioxide (NO) exposure on neurology clinic visits (NCVs) for headache onsets.
Records of NCVs for headaches, concentrations of ambient NO, and meteorological variables were collected in Wuhan, China, from January 1st, 2017, to November 30th, 2019. A time-series study was conducted to investigate the short-term effects of NO exposure on daily NCVs for headaches. Stratified analyses were also computed according to season, age, and sex, and the exposure-response (E-R) curve was then plotted.
A total of 11,436 records of NCVs for headaches were enrolled in our study during the period. A 10-μg/m increase of ambient NO corresponded to a 3.64% elevation of daily NCVs for headaches (95%CI: 1.02%, 6.32%, P = 0.006). Moreover, females aged less than 50 years of age were more susceptible compared to males (4.10% vs. 2.97%, P = 0.007). The short-term effects of NO exposure on daily NCVs for headaches were stronger in cool seasons than in warm seasons (6.31% vs. 0.79%, P = 0.0009).
Our findings highlight that short-term exposure to ambient NO positively correlated with NCVs for headaches in Wuhan, China, and the adverse effects varied by season, age, and sex.
先前的研究表明，空气污染对发达国家头痛发作有不利影响。然而，证据仅限于暴露于空气污染物对头痛发作的影响。在这项研究中，我们旨在探讨二氧化氮（NO）暴露对神经内科就诊（NCV）治疗头痛发作的影响。
本研究收集了 2017 年 1 月 1 日至 2019 年 11 月 30 日期间中国武汉的 NCV 治疗头痛记录、环境 NO 浓度和气象变量。采用时间序列研究来探讨 NO 暴露对每日 NCV 治疗头痛的短期影响。还根据季节、年龄和性别进行了分层分析，并绘制了暴露反应（E-R）曲线。
在研究期间共纳入了 11436 例 NCV 治疗头痛记录。环境 NO 增加 10μg/m 对应于每日 NCV 治疗头痛的升高 3.64%（95%CI：1.02%，6.32%，P=0.006）。此外，与男性相比，年龄小于 50 岁的女性更容易受到影响（4.10%比 2.97%，P=0.007）。NO 暴露对每日 NCV 治疗头痛的短期影响在凉爽季节比温暖季节更强（6.31%比 0.79%，P=0.0009）。
我们的研究结果表明，环境 NO 的短期暴露与中国武汉的 NCV 治疗头痛呈正相关，其不良影响因季节、年龄和性别而异。
