Department of Cardiovascular Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.
Hormones (Athens). 2023 Jun;22(2):331-341. doi: 10.1007/s42000-023-00448-4. Epub 2023 Mar 27.
Triglyceride-glucose (TyG) is correlated with cardiovascular events caused by insulin resistance (IR). The aim of this study was to analyze the relationship between TyG and its related indicators and IR among US adults from 2007 to 2018 in the National Health and Nutrition Examination Survey (NHANES) database so as to identify more accurate and reliable predictors of IR.
This is a cross-sectional study including 9884 participants (2255 with IR and 7629 without IR). TyG, TyG-body mass index (TyG-BMI), TyG waist circumference (TyG-WC), and TyG waist-to-height ratio (TyG-WtHR) were measured using standard formulas.
TyG, TyG-BMI, TyG-WC, and TyG-WtHR were significantly correlated with IR in the general population, with TyG-WC being the most strongly correlated, with an odds ratio of 8.00 (95% confidence interval 5.05-12.67) for the fourth quartile of TyG-WC compared with the first quartile in the adjusted model. Receiver operating characteristic (ROC) analysis of the participants showed that the maximum area under the TyG-WC curve was 0.8491, which was significantly higher than that of the other three indicators. Moreover, this trend was stable both among people of both genders and among patients with coronary heart disease (CHD), hypertension, and diabetes.
The present study confirms that the TyG-WC index is more successful than TyG alone in identifying IR. In addition, our findings demonstrate that TyG-WC is a simple and effective marker for screening the general US adult population and those with CHD, hypertension, and diabetes and can be effectively used in clinical practice.
甘油三酯-葡萄糖（TyG）与胰岛素抵抗（IR）引起的心血管事件相关。本研究旨在分析美国成年人 2007 年至 2018 年国家健康和营养检查调查（NHANES）数据库中 TyG 及其相关指标与 IR 之间的关系，以确定更准确和可靠的 IR 预测指标。
这是一项横断面研究，纳入了 9884 名参与者（2255 名 IR 患者和 7629 名非 IR 患者）。采用标准公式测量 TyG、TyG-体重指数（TyG-BMI）、TyG 腰围（TyG-WC）和 TyG 腰高比（TyG-WtHR）。
TyG、TyG-BMI、TyG-WC 和 TyG-WtHR 在一般人群中与 IR 显著相关，其中 TyG-WC 相关性最强，与 TyG-WC 四分位间距最高组相比，调整模型中四分位间距最低组的 IR 比值为 8.00（95%置信区间 5.05-12.67）。参与者的受试者工作特征（ROC）分析显示，TyG-WC 曲线下面积最大为 0.8491，明显高于其他三个指标。此外，这种趋势在男性和女性人群以及冠心病（CHD）、高血压和糖尿病患者中均保持稳定。
本研究证实，与单独使用 TyG 相比，TyG-WC 指数在识别 IR 方面更成功。此外，我们的研究结果表明，TyG-WC 是一种简单有效的标志物，可用于筛查一般美国成年人群体以及 CHD、高血压和糖尿病患者，可以在临床实践中有效使用。
