Peng Yiwei, Li Ling, Li Minqi, Wang Jie, Long Tianyao, Zheng Liuyangyi, Tan Xuan, Hong Xiuqin
Clinical Epidemiology Research Office, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
Key Laboratory of Molecular Epidemiology, Hunan Normal University, Changsha, China.
Front Cardiovasc Med. 2025 Jul 10;12:1589488. doi: 10.3389/fcvm.2025.1589488. eCollection 2025.
The triglyceride-glucose index combined with waist circumference (TyG-WC) has good predictive performance for cardiovascular disease, but the relationship of TyG-WC with H-type hypertension (HTH) is still unclear.
To explore the association between TyG-WC and HTH, and provide theoretical basis for the prevention and treatment of HTH in the community population.
The study used multi-stage cluster random sampling to collect representative samples from urban and rural populations in Hunan Province. HTH was defined as primary hypertension with homocysteine ≥15 μmol/L. Logistic regression and restricted cubic spline (RCS) models analyzed the TyG-WC index's association with HTH. Receiver operating characteristic (ROC) curve analysis compared TyG, WC, TyG-BMI, and TyG-WC in diagnosing HTH. An additive interaction analysis evaluated the synergistic effect of TyG and WC on HTH. Comparative analyses were conducted on the association between the TyG-WC index and both types of hypertension in the general population.
4,012 subjects were included in this study, and the prevalence of HTH was 19.77%. After adjusting for multiple confounding factors, participants with the highest quartile of TyG-WC had a higher risk of developing HTH compared to those with the lowest quartile of TyG-WC, with OR values of 3.182 (95% CI: 2.370-4.272, < 0.001). RCS analysis revealed a significant correlation between TyG-WC index and HTH (overall trend < 0.001). The correlation between TyG-WC and HTH still existed in subgroup analysis. ROC curve analysis showed that TyG-WC has higher predictive value for HTH compared to other variables (AUC = 0.676, 95%CI: 0.655-0.696, = 0.010). Interaction analysis showed an additive effect between TyG and WC, with individuals having both high TyG and high WC exhibiting a 1.66 times higher HTH risk than those with low TyG and low WC. TyG-WC demonstrated a stronger association with HTH than with general hypertension.
The TyG-WC index has high predictive value in identifying HTH, being a promising biomarker for HTH. Our findings provide theoretical basis for the prevention and treatment of HTH in the community population by controlling blood lipid, blood glucose, and waist circumference levels.
甘油三酯-血糖指数联合腰围（TyG-WC）对心血管疾病具有良好的预测性能，但TyG-WC与H型高血压（HTH）的关系仍不明确。
探讨TyG-WC与HTH之间的关联，为社区人群HTH的防治提供理论依据。
本研究采用多阶段整群随机抽样方法，从湖南省城乡人群中收集具有代表性的样本。HTH定义为同型半胱氨酸≥15 μmol/L的原发性高血压。采用逻辑回归和受限立方样条（RCS）模型分析TyG-WC指数与HTH的关联。采用受试者工作特征（ROC）曲线分析比较TyG、WC、TyG-BMI和TyG-WC在诊断HTH方面的作用。采用相加交互作用分析评估TyG和WC对HTH的协同作用。对TyG-WC指数与一般人群中两种类型高血压之间的关联进行比较分析。
本研究共纳入4012名受试者，HTH患病率为19.77%。在调整多个混杂因素后，TyG-WC最高四分位数的参与者患HTH的风险高于TyG-WC最低四分位数的参与者，OR值为3.182（95%CI：2.370-4.272，<0.001）。RCS分析显示TyG-WC指数与HTH之间存在显著相关性（总体趋势<0.001）。亚组分析中TyG-WC与HTH之间的相关性仍然存在。ROC曲线分析显示，与其他变量相比，TyG-WC对HTH具有更高的预测价值（AUC=0.676，95%CI：0.655-0.696，P=0.010）。交互作用分析显示TyG和WC之间存在相加效应，TyG和WC均高的个体患HTH的风险比TyG和WC均低的个体高1.66倍。TyG-WC与HTH的关联比与一般高血压的关联更强。
TyG-WC指数在识别HTH方面具有较高的预测价值，是一种有前景的HTH生物标志物。我们的研究结果为通过控制血脂、血糖和腰围水平来防治社区人群HTH提供了理论依据。
