Medical College of Wisconsin, Milwaukee, WI, United States of America.
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States of America.
PLoS One. 2023 Mar 27;18(3):e0283460. doi: 10.1371/journal.pone.0283460. eCollection 2023.
Awake craniotomies provide unique and invaluable scientific opportunities for neurophysiological experimentation in consenting human subjects. While such experimentation carries a long history, rigorous reporting of methodologies focusing on synchronizing data across multiple platforms is not universally reported and often not translatable to across operating rooms, facilities, or behavioral tasks. Therefore, here we detail an intraoperative data synchronization methodology designed to work across multiple commercially available platforms to collect behavioral and surgical field videos, electrocorticography, brain stimulation timing, continuous finger joint angles, and continuous finger force production. Our technique was developed to be nonobstructive to operating room (OR) staff and generalizable to a variety of hand-based tasks. We hope that the detailed reporting of our methods will support the scientific rigor and reproducibility of future studies, as well as aid other groups interested in performing related experiments.
清醒开颅术为同意参与的人类受试者中的神经生理学实验提供了独特且宝贵的科学机会。虽然此类实验具有悠久的历史，但对专注于跨多个平台同步数据的方法进行严格报告并未得到普遍报告，并且通常无法在不同手术室、设施或行为任务之间转换。因此，在这里，我们详细介绍了一种跨多个商业可用平台工作的术中数据同步方法，以收集行为和手术现场视频、皮质电图、脑刺激时间、连续指关节角度和连续手指力量产生。我们的技术旨在不干扰手术室（OR）工作人员，并可推广到各种基于手部的任务。我们希望详细报告我们的方法将支持未来研究的科学严谨性和可重复性，并帮助其他有兴趣进行相关实验的小组。
