Faculty of Medicine, Laboratory of Pathophysiology of EXercise (LPEX), School of Kinesiology and Physical Activity Sciences, University of Montreal, Montreal, QC,Canada.
Sainte-Justine University Health Center, Research Center, Montreal, QC,Canada.
J Phys Act Health. 2023 Mar 27;20(6):522-530. doi: 10.1123/jpah.2022-0179. Print 2023 Jun 1.
Childhood acute lymphoblastic leukemia survivors' anthracycline-induced cardiotoxicity could be prevented with good cardiorespiratory fitness levels and regular physical activity. This cross-sectional study aimed to assess the association between cardiorespiratory fitness and physical activity with cardiac magnetic resonance parameters.
A total of 96 childhood acute lymphoblastic leukemia survivors underwent a maximal cardiopulmonary exercise test and answered physical activity questionnaires. We calculated the odds ratio of the preventive fraction of regular physical activity (≥150 min/wk) and adequate cardiorespiratory fitness levels (above the median ≥31.4 mL·kg-1·min-1) on cardiac magnetic resonance parameters (left ventricular [LV] and right ventricular [RV] morphological and functional parameters).
An adequate cardiorespiratory fitness was associated with a significant preventive fraction for LV (up to 84% for LV end-diastolic volume) and RV volumes (up to 88% for RV end-systolic volume). The adjusted analyses highlighted a preventive fraction of 36% to 91% between an adequate cardiorespiratory fitness and LV and RV parameters, late gadolinium enhancement fibrosis, and cardiac magnetic resonance relaxation times. No associations were reported with regular physical activity.
This study provides additional evidence regarding the benefits of an adequate cardiorespiratory fitness level for childhood cancer survivors' cardiac health.
童年期急性淋巴细胞白血病幸存者的蒽环类药物诱导性心脏毒性可以通过良好的心肺适能水平和规律的身体活动来预防。本横断面研究旨在评估心肺适能与身体活动与心脏磁共振参数之间的关联。
共有 96 名童年期急性淋巴细胞白血病幸存者接受了最大心肺运动测试，并回答了身体活动问卷。我们计算了规律身体活动（≥150 分钟/周）和足够心肺适能水平（高于中位数≥31.4 毫升·千克-1·分钟-1）对心脏磁共振参数（左心室[LV]和右心室[RV]形态和功能参数）的预防分数的比值。
足够的心肺适能与 LV（LV 舒张末期容积最高可达 84%）和 RV 容积（RV 收缩末期容积最高可达 88%）的显著预防分数相关。调整后的分析强调了足够的心肺适能与 LV 和 RV 参数、晚期钆增强纤维化和心脏磁共振弛豫时间之间的预防分数为 36%至 91%。与规律身体活动无相关性。
本研究为儿童癌症幸存者心脏健康中足够的心肺适能水平的益处提供了额外的证据。
