Young Kiana M, Rush Justin L, Lepley Adam S, Girmann Adam M, Norte Grant E
Department of Exercise and Rehabilitation Sciences, College of Health and Human Services, The University of Toledo, Toledo, OH, United States.
Department of Exercise and Rehabilitation Sciences, College of Health and Human Services, The University of Toledo, Toledo, OH, United States.
Brain Res. 2023 Jun 1;1808:148348. doi: 10.1016/j.brainres.2023.148348. Epub 2023 Mar 25.
Recording transcranial magnetic stimulation-derived measures during a closed kinetic chain task can serve as a functional technique to assess corticomotor function, which may have implications for activities of daily living or lower extremity injury in physically active individuals. Given the novelty of TMS use in this way, our purpose was to first determine the intersession reliability of quadriceps corticospinal excitability during a single-leg squat. We used a descriptive laboratory study to assess 20 physically active females (22.1 ± 2.5 years, 1.7 ± 0.7 m, 66.3 ± 13.6 kg, Tegner Activity Scale: 5.90 ± 1.12) over a 14-day period. Two-way mixed effects Intraclass Correlation Coefficients (3,1) (ICC) for absolute agreement were used to assess intersession reliability. The active motor threshold (AMT) and normalized motor evoked potential (MEP) amplitudes were assessed in the vastus medialis of each limb. The dominant limb AMTs demonstrated moderate-to-good reliability (ICC = 0.771, 95% CI = 0.51-0.90; p < 0.001). The non-dominant limb AMTs (ICC = 0.364, 95% CI = 0.00-0.68, p = 0.047), dominant limb MEPs (ICC = 0.192, 95% CI = 0.00-0.71; p = 0.340), and non-dominant limb MEPs (ICC = 0.272, 95% CI = 0.00-0.71; p = 0.235) demonstrated poor-to-moderate reliability. These findings may provide insight into corticomotor function during activities requiring weight-bearing, single-leg movement. However, variability in agreement suggests further work is warranted to improve the standardization of this technique prior to incorporating in clinical outcomes research.
在闭链运动任务期间记录经颅磁刺激衍生的指标，可作为评估皮质运动功能的一种功能技术，这可能对体力活动个体的日常生活活动或下肢损伤具有重要意义。鉴于以这种方式使用经颅磁刺激的新颖性，我们的目的是首先确定单腿深蹲期间股四头肌皮质脊髓兴奋性的会话间可靠性。我们采用描述性实验室研究，在14天的时间里评估了20名体力活动女性（22.1±2.5岁，身高1.7±0.7米，体重66.3±13.6千克，特格纳活动量表：5.90±1.12）。使用双向混合效应组内相关系数（3,1）（ICC）评估绝对一致性的会话间可靠性。在每个肢体的股内侧肌中评估主动运动阈值（AMT）和标准化运动诱发电位（MEP）幅度。优势肢体的AMT显示出中等到良好的可靠性（ICC = 0.771，95%可信区间 = 0.51 - 0.90；p < 0.001）。非优势肢体的AMT（ICC = 0.364，95%可信区间 = 0.00 - 0.68，p = 0.047）、优势肢体的MEP（ICC = 0.192，95%可信区间 = 0.00 - 0.71；p = 0.340）和非优势肢体的MEP（ICC = 0.272，95%可信区间 = 0.00 - 0.71；p = 0.235）显示出低到中等的可靠性。这些发现可能为负重单腿运动活动期间的皮质运动功能提供见解。然而，一致性的变异性表明，在将该技术纳入临床结局研究之前，有必要进一步开展工作以提高其标准化程度。
