Donnini R, Linoli G
Laboratorio di Analisi Chimiche e di Anatomia Patologica, U.S.L. Zona n. 23, Presidio Ospedaliero, Arezzo, Italia.
Pediatr Med Chir. 1987 Jul-Aug;9(4):431-5.
We have determined total IgE in serum of 640 healthy subjects and 620 atopic asthmatic subjects of both sexes, aged between 1 and 70. Values of antibody E after decimal logarithmic transformation have acquired a path as in Gaussian curves. Healthy subjects, chosen for sex and for unit of ten years of life, constantly show mean values in serum have appeared in the first and second decade of life in males; in second and third in females. Those facts should be originated by genetic factors connected with sex. We have described physiopathological conditions in which an increase of serum IgE could be connected with genetic factors and mechanism ascertained today, both responsible for the control of IgE.
我们测定了640名年龄在1岁至70岁之间的健康受试者和620名特应性哮喘受试者（男女均有）血清中的总IgE。经十进制对数转换后的E抗体值呈现出高斯曲线那样的轨迹。按性别和每十岁年龄段选取的健康受试者，其血清平均值在男性中常出现在生命的第一个和第二个十年；在女性中则出现在第二个和第三个十年。这些情况可能是由与性别相关的遗传因素引起的。我们已经描述了血清IgE升高可能与遗传因素相关的生理病理状况以及目前确定的、负责控制IgE的机制。
