Neffen H, Crisci C D, Busaniche H, Yañez A
Allergol Immunopathol (Madr). 1986 Sep-Oct;14(5):413-8.
We studied 1,030 patients of both sexes, classified according to atopic and non-atopic, those suffering from bronchial asthma (AB), rhinitis (R) or associated AB and R, with ages between 3 months to 62 years. Total IgE, serum IgA and secretory IgA were determined in all of them in order to establish their values and to make the corresponding comparisons. Serum IgA did not show any difference in both groups, while secretory IgA showed lower values in atopic patients than non-atopic patients during childhood. Later on, their values reached a similar level. Total IgE values in atopics significantly differed from non-atopic values at all ages. There was a negative correlation coefficient between total IgE and secretory IgA in the 6 years old patients' group, and in adults. Our results suggest that IgE synthesis, genetically determined in atopics, may be influenced to higher levels in patients with lower secretory IgA levels. This latter factor, as we only measured total secretory non-specific IgA level, must be considered of relative importance.
我们研究了1030名男女患者，根据是否患有特应性疾病分为特应性和非特应性两组，这些患者患有支气管哮喘（AB）、鼻炎（R）或AB与R并发，年龄在3个月至62岁之间。对所有患者测定了总IgE、血清IgA和分泌型IgA，以确定其数值并进行相应比较。血清IgA在两组中未显示出任何差异，而在儿童期，分泌型IgA在特应性患者中的值低于非特应性患者。后来，它们的值达到了相似的水平。在所有年龄段，特应性患者的总IgE值与非特应性患者的总IgE值均有显著差异。在6岁患者组和成人中，总IgE与分泌型IgA之间存在负相关系数。我们的结果表明，特应性患者中由基因决定的IgE合成，在分泌型IgA水平较低的患者中可能会受到更高水平的影响。由于我们仅测量了总分泌型非特异性IgA水平，后一个因素的重要性必须被视为相对的。
