Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Nat Rev Immunol. 2023 Nov;23(11):705-719. doi: 10.1038/s41577-023-00857-x. Epub 2023 Mar 27.
The spleen is a gatekeeper of systemic immunity where immune responses against blood-borne pathogens are initiated and sustained. Non-haematopoietic stromal cells construct microanatomical niches in the spleen that make diverse contributions to physiological spleen functions and regulate the homeostasis of immune cells. Additional signals from spleen autonomic nerves also modify immune responses. Recent insight into the diversity of the splenic fibroblastic stromal cells has revised our understanding of how these cells help to orchestrate splenic responses to infection and contribute to immune responses. In this Review, we examine our current understanding of how stromal niches and neuroimmune circuits direct the immunological functions of the spleen, with a focus on T cell immunity.
脾脏是全身免疫系统的守门员，在此处启动并维持针对血源性病原体的免疫反应。非造血基质细胞在脾脏中构建微观解剖学龛位，为生理脾脏功能做出多样化贡献，并调节免疫细胞的动态平衡。来自脾脏自主神经的附加信号也可调节免疫反应。最近对脾脏成纤维基质细胞多样性的深入了解，修正了我们对这些细胞如何帮助协调脾脏对感染的反应以及促进免疫反应的理解。在这篇综述中，我们研究了目前对基质龛位和神经免疫回路如何指导脾脏免疫功能的理解，重点关注 T 细胞免疫。
