Mueller Scott N, Germain Ronald N
Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010 Victoria, Australia.
Nat Rev Immunol. 2009 Sep;9(9):618-29. doi: 10.1038/nri2588. Epub 2009 Jul 31.
A defining characteristic of the immune system is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions that underlie homeostatic regulation, peripheral tolerance and the effective development of adaptive immune responses take place. What has only recently been recognized is the role that non-haematopoietic stromal elements have in many aspects of immune cell migration, activation and survival. In this Review, we summarize our current understanding of lymphoid compartment stromal cells, examine their possible heterogeneity, discuss how these cells contribute to immune homeostasis and the efficient initiation of adaptive immune responses, and highlight how targeting of these elements by some pathogens can influence the host immune response.
免疫系统的一个决定性特征是其许多组成细胞不断通过二级淋巴组织，主要是脾脏和淋巴结，在这些组织中发生了构成稳态调节、外周耐受和适应性免疫反应有效发展基础的关键相互作用。直到最近才认识到的是，非造血基质成分在免疫细胞迁移、激活和存活的许多方面所起的作用。在本综述中，我们总结了目前对淋巴区室基质细胞的理解，研究了它们可能存在的异质性，讨论了这些细胞如何促进免疫稳态和适应性免疫反应的有效启动，并强调了一些病原体对这些成分的靶向作用如何影响宿主免疫反应。
