Satoh Michihiro, Yoshida Tomoya, Metoki Hirohito, Murakami Takahisa, Tatsumi Yukako, Hirose Takuo, Takabatake Kyosuke, Tsubota-Utsugi Megumi, Hara Azusa, Nomura Kyoko, Asayama Kei, Kikuya Masahiro, Hozawa Atsushi, Imai Yutaka, Ohkubo Takayoshi
Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-Ku, Sendai, Miyagi, 983-8536, Japan.
Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Sci Rep. 2023 Mar 27;13(1):4985. doi: 10.1038/s41598-023-31861-9.
There is little information about the reproducibility of the white coat effect, which was treated as a continuous variable. To investigate a long-term interval reproducibility of the white-coat effect as a continuous variable. We selected 153 participants without antihypertensive treatment (men, 22.9%; age, 64.4 years) from the general population of Ohasama, Japan, to assess the repeatedly measured white-coat effect (the difference between blood pressures at the office and home) in a 4-year interval. The reproducibility was assessed by testing the intraclass correlation coefficient (two-way random effect model-single measures). The white-coat effect for systolic/diastolic blood pressure slightly decreased by 0.17/1.56 mmHg at the 4-year visit on average. The Bland-Altman plots showed no significant systemic error for the white-coat effects (P ≥ 0.24). The intraclass correlation coefficient (95% confidence interval) of the white-coat effect for systolic blood pressure, office systolic blood pressure, and home systolic blood pressure were 0.41 (0.27-0.53), 0.64 (0.52-0.74), and 0.74 (0.47-0.86), respectively. Change in the white-coat effect was mainly affected by a change in office blood pressure. Long-term reproducibility of the white-coat effect is limited in the general population without antihypertensive treatment. The change in the white-coat effect is mainly caused by office blood pressure variation.
关于被视为连续变量的白大衣效应的可重复性，相关信息较少。为了研究作为连续变量的白大衣效应的长期间隔可重复性。我们从日本大岛的普通人群中选取了153名未接受抗高血压治疗的参与者（男性占22.9%；年龄为64.4岁），以评估4年间隔内重复测量的白大衣效应（诊室血压与家庭血压之间的差值）。通过测试组内相关系数（双向随机效应模型 - 单次测量）来评估可重复性。在4年随访时，收缩压/舒张压的白大衣效应平均略有下降，分别下降了0.17/1.56 mmHg。Bland - Altman图显示白大衣效应无显著的系统误差（P≥0.24）。收缩压的白大衣效应、诊室收缩压和家庭收缩压的组内相关系数（95%置信区间）分别为0.41（0.27 - 0.53）、0.64（0.52 - 0.74）和0.74（0.47 - 0.86）。白大衣效应的变化主要受诊室血压变化的影响。在未接受抗高血压治疗的普通人群中，白大衣效应的长期可重复性有限。白大衣效应的变化主要由诊室血压波动引起。
