Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Department of Medicine, University of Ottawa, Ottawa, Canada.
Adipocyte. 2023 Dec;12(1):2194034. doi: 10.1080/21623945.2023.2194034.
The renin-angiotensin system (RAS) operates within adipose tissue. Obesity-related changes can affect adipose RAS, predisposing to hypertension, type 2 diabetes, and possibly severe COVID-19. We evaluated the research on human adipose RAS and identified gaps in the literature. Medline (Ovid), Embase (Ovid), Web of Science, Scopus, and 1findr were searched to identify relevant studies. Fifty primary studies met our inclusion criteria for analysis. Expression of RAS components ( = 14), role in differentiation ( = 14), association with inflammation ( = 15) or blood pressure ( = 7) were investigated. We found (1) obesity-related changes in RAS were frequently studied (30%); (2) an upswing of articles investigating adipose ACE-2 expression since the COVID-19 pandemic; (3) a paucity of papers on AT2R and Ang (1-7)/MasR which counterbalance Ang II/ART1; (4) weight loss lowered adipose ACE-2 mRNA expression; and (5) angiotensin receptor blockers (ARBs) reduced deleterious effects of angiotensin II. Overall, these studies link Ang II/ATR1 signalling to impaired adipogenesis and a pro-inflammatory dysfunctional adipose tissue, with ATR1 blockade limiting these responses. ACE-2 may mitigate Ang II effects by converting it to Ang(1-7) which binds MasR. More work is needed to understand adipose RAS in various pathologic states such as obesity and COVID-19 infection.T.
肾素-血管紧张素系统 (RAS) 在脂肪组织中发挥作用。肥胖相关的变化可能会影响脂肪组织 RAS，导致高血压、2 型糖尿病，甚至可能导致严重的 COVID-19。我们评估了人类脂肪组织 RAS 的研究，并发现了文献中的空白。通过 Medline (Ovid)、Embase (Ovid)、Web of Science、Scopus 和 1findr 搜索确定了相关研究。有 50 项主要研究符合我们的分析纳入标准。研究了 RAS 成分的表达（ = 14）、分化中的作用（ = 14）、与炎症（ = 15）或血压（ = 7）的关系。我们发现：(1) RAS 的肥胖相关变化经常被研究（30%）；(2) 自 COVID-19 大流行以来，研究脂肪组织 ACE-2 表达的文章数量增加；(3) 关于 AT2R 和 Ang (1-7)/MasR 的论文很少，这些物质可以平衡 Ang II/ART1；(4) 体重减轻会降低脂肪组织 ACE-2 mRNA 表达；(5) 血管紧张素受体阻滞剂 (ARB) 可减少血管紧张素 II 的有害作用。总的来说，这些研究将 Ang II/ATR1 信号与受损的脂肪生成和促炎功能障碍的脂肪组织联系起来，ATR1 阻断限制了这些反应。ACE-2 可以通过将其转化为结合 MasR 的 Ang(1-7)来减轻 Ang II 的作用。需要更多的工作来了解肥胖和 COVID-19 感染等各种病理状态下的脂肪组织 RAS。
