Li Jinxia, Xie Jingjun, Guo Xiaoqing, Fu Ruiyang, Wang Yaling, Guan Xinjun
Huzhou Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Huzhou, Zhejiang, 313000, People's Republic of China.
The First People's Hospital of Huzhou, Huzhou, Zhejiang, 313000, People's Republic of China.
Int J Gen Med. 2023 Mar 21;16:1017-1027. doi: 10.2147/IJGM.S405977. eCollection 2023.
The aim of this research is to analyze the effects of mind-regulation acupuncture on serum ghrelin, gastric inhibitory polypeptide, leptin, and insulin levels, fatigue, quality of sleep, depression, and quality of life in survivors of breast cancer with cancer-related fatigue.
Total 136 breast cancer survivors with cancer-related fatigue were randomly allocated to the mind-regulation acupuncture group and the control group in a 1:1 ratio, with 68 cases in each group. Finally, 57 cases each in both groups completed the study. The serum ghrelin, gastric inhibitory polypeptide, leptin, and insulin levels were measured in pre-treatment and post-treatment. The 20-item Multidimensional Fatigue Symptom Inventory, Pittsburgh Sleep Quality Index, Hamilton Depression Scale, and Karnofsky Performance Status were used to evaluate patients' fatigue, quality of sleep, symptoms of depression, and quality of life, respectively.
In post-treatment, the serum ghrelin, gastric inhibitory polypeptide, leptin, and insulin levels significantly reduced, 20-item Multidimensional Fatigue Symptom Inventory, Pittsburgh Sleep Quality Index, and Hamilton Depression scores were remarkably decreased, whereas the Karnofsky Performance Status scores were significantly increased in mind-regulation acupuncture group and control group comparing to those pre-treatment, while those in mind-regulation acupuncture group changed more significantly. The 20-item Multidimensional Fatigue Symptom Inventory, Pittsburgh Sleep Quality Index, and Hamilton Depression scores were remarkably lower, and remarkably higher Karnofsky Performance Status scores in the mind-regulation acupuncture group were seen than those in the control group.
Mind-regulation acupuncture could reduce serum ghrelin, gastric inhibitory polypeptide, leptin, and insulin levels of breast cancer survivors with cancer-related fatigue. In addition, it alleviates cancer-related fatigue, sleep disturbance, and depression in these survivors and improves their quality of life. Therefore, mind-regulation acupuncture may have potential as an alternative and complementary therapy for breast cancer survivors with cancer-related fatigue.
本研究旨在分析调神针刺对乳腺癌相关疲劳幸存者血清胃饥饿素、胃抑制多肽、瘦素和胰岛素水平、疲劳、睡眠质量、抑郁及生活质量的影响。
将136例有癌症相关疲劳的乳腺癌幸存者按1:1比例随机分为调神针刺组和对照组，每组68例。最终，两组各有57例完成研究。于治疗前和治疗后测量血清胃饥饿素、胃抑制多肽、瘦素和胰岛素水平。分别采用20项多维疲劳症状量表、匹兹堡睡眠质量指数、汉密尔顿抑郁量表和卡氏功能状态量表评估患者的疲劳、睡眠质量、抑郁症状和生活质量。
治疗后，调神针刺组和对照组血清胃饥饿素、胃抑制多肽、瘦素和胰岛素水平均显著降低，20项多维疲劳症状量表、匹兹堡睡眠质量指数及汉密尔顿抑郁量表评分均显著下降，而卡氏功能状态量表评分较治疗前显著升高，且调神针刺组变化更显著。调神针刺组20项多维疲劳症状量表、匹兹堡睡眠质量指数及汉密尔顿抑郁量表评分显著低于对照组，卡氏功能状态量表评分显著高于对照组。
调神针刺可降低有癌症相关疲劳的乳腺癌幸存者血清胃饥饿素、胃抑制多肽、瘦素和胰岛素水平。此外，它可减轻这些幸存者的癌症相关疲劳、睡眠障碍和抑郁，提高其生活质量。因此，调神针刺可能作为有癌症相关疲劳的乳腺癌幸存者的一种替代和补充疗法具有潜力。
