Kataoka Hiroshi, Obayashi Kenji, Tai Yoshiaki, Sugie Kazuma, Saeki Keigo
Department of Neurology, Nara Medical University, Nara, Japan.
Department of Epidemiology, Nara Medical University, Nara, Japan.
Clin Park Relat Disord. 2023;8:100194. doi: 10.1016/j.prdoa.2023.100194. Epub 2023 Mar 22.
The cumulative number of patients has increased through the four waves of the pandemic in Japan. Many people experienced mental stress due to the fear of infection, and restrictions of leaving the house and leisure activities. No longitudinal study has assessed the fluctuation of neuropsychiatric symptoms during the COVID-19 pandemic using the same scale. We examined changes in non-motor symptoms, and the scores of a Parkinson's Disease (PD)-specific questionnaire between the early and later periods during the COVID-19 pandemic.
We conducted a questionnaire survey during the first wave (from February to April 2020) and the fourth wave of the COVID-19 pandemic (from March to April 2021). We compared the number of symptoms from the two periods.
Compared with the first wave, the Geriatric Depression Scale score was significantly higher in the fourth wave of the pandemic (median score of GDS: 4.00 vs. 5.50, p = 0.022). Consistently, the scores of symptoms on MDS-UPDRS part 1 in the fourth wave were significantly higher in hygiene (p = 0.033), handwriting (p = 0.033), performing hobbies and other activities (p = 0.035), and turning in bed (p = 0.046) than in the first wave.
Our observation over a year between the early and later phases of the COVID-19 pandemic showed an increase in the severity of depression in patients with PD.
在日本，随着新冠疫情的四波流行，患者累计数量有所增加。许多人因担心感染、出行限制和休闲活动受限而经历了精神压力。尚无纵向研究使用相同量表评估新冠疫情期间神经精神症状的波动情况。我们研究了新冠疫情早期和后期帕金森病（PD）非运动症状及特定问卷评分的变化。
我们在新冠疫情第一波（2020年2月至4月）和第四波（2021年3月至4月）期间进行了问卷调查。我们比较了两个时期的症状数量。
与第一波相比，疫情第四波时老年抑郁量表评分显著更高（GDS中位数评分：4.00对5.50，p = 0.022）。同样，第四波时MDS-UPDRS第1部分中卫生（p = 0.033）、书写（p = 0.033）、进行爱好和其他活动（p = 0.035）以及在床上翻身（p = 0.046）方面的症状评分显著高于第一波。
我们在新冠疫情早期和后期一年间的观察显示，PD患者的抑郁严重程度有所增加。
