Shalash Ali, Helmy Asmaa, Salama Mohamed, Gaber Ahmed, El-Belkimy Mahmoud, Hamid Eman
Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Institute of Global Health and Human Ecology (I-GHHE), the American University in Cairo, Cairo, Egypt.
NPJ Parkinsons Dis. 2022 Aug 31;8(1):111. doi: 10.1038/s41531-022-00376-x.
Further studies are required to investigate the impact of the COVID-19 pandemic on Parkinson's disease (PD) progression. This study investigated the motor and non-motor progression of people with PD (PWP) at 6 months during the COVID-19 pandemic compared with that during the pre-pandemic period. Patients were recruited from Ain Shams University Hospitals, Cairo, in the period between April 2019 and December 2020. Fifty patients were included, of whom 17 and 33 patients were followed for 6 months before and during the pandemic, respectively. All patients were assessed at baseline and at 6 months using the MDS-UPDRS, Schwab and England scale (S&E), Hoehn and Yahr scale (H&Y), Berg Balance Scale, Timed Up and Go test (TUG), International Physical Activity Questionnaire, New Freezing of Gait Questionnaire, Non-Motor Symptoms Scale, and Beck Depression Inventory (BDI). Both groups were matched in age, gender, and disease characteristics. Patients followed during the pandemic showed more significant worsening of the total, part I and motor part of MDS-UPDRS, and balance scores (p < 0.001) than those followed during the pre-COVID-19 period. Gait (TUG), balance, and physical activity worsening were significantly correlated with baseline BDI, gait and balance scores, total and part I MDS-UPDRS scores, H&Y, and S&E OFF scores. Gait deterioration (TUG) was correlated with baseline physical activity (r = -0.510, p = 0.002). PWP showed worsening of motor and non-motor symptoms during the COVID-19 pandemic at the 6-month follow-up. Worsening of gait, balance, and physical activity was correlated with baseline motor and physical activity OFF scores.
需要进一步研究来调查新冠疫情对帕金森病（PD）进展的影响。本研究调查了新冠疫情期间与疫情前相比，帕金森病患者（PWP）在6个月时的运动和非运动进展情况。患者于2019年4月至2020年12月期间从开罗的艾因夏姆斯大学医院招募。共纳入50例患者，其中17例和33例患者分别在疫情前和疫情期间随访6个月。所有患者在基线和6个月时使用MDS-UPDRS、施瓦布和英格兰量表（S&E）、霍恩和雅尔量表（H&Y）、伯格平衡量表、定时起立行走测试（TUG）、国际体力活动问卷、新的步态冻结问卷、非运动症状量表和贝克抑郁量表（BDI）进行评估。两组在年龄、性别和疾病特征方面相匹配。与新冠疫情前随访的患者相比，疫情期间随访的患者在MDS-UPDRS总分、第一部分和运动部分以及平衡评分方面恶化更为显著（p < 0.001）。步态（TUG）、平衡和体力活动的恶化与基线BDI、步态和平衡评分、MDS-UPDRS总分和第一部分评分、H&Y以及S&E关期评分显著相关。步态恶化（TUG）与基线体力活动相关（r = -0.510，p = 0.002）。在6个月的随访中，帕金森病患者在新冠疫情期间运动和非运动症状出现恶化。步态、平衡和体力活动的恶化与基线运动和体力活动关期评分相关。
