Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Parkinsonism Relat Disord. 2020 Nov;80:148-151. doi: 10.1016/j.parkreldis.2020.09.034. Epub 2020 Sep 23.
The coronavirus disease 2019 (COVID-19) pandemic has disrupted everyday life of Parkinson's disease (PD) patients, but its clinical impact has not been illustrated. In this study, we investigated the change in physical activity and subsequently clinical symptoms of PD during the COVID-19 pandemic.
We enrolled PD patients who were able to ambulate independently and had visited our clinic at Samsung Medical Centre from December 2019 to January 2020 (baseline) and in May 2020 (follow-up during the COVID-19 crisis), and divided them into either 'the sustained exercise group' or 'the reduced exercise group'. Then, we assessed the change in the exercise and clinical features between these two groups over the study period.
A total of 100 subjects were recruited. During the COVID-19 pandemic, the amount, duration and frequency of exercise were reduced. There was decrease in number of patients who do indoor-solo exercise and increase in that of patients who do not exercise. One third reported subjective worsening of both motor and non-motor features, although Unified PD Rating Scale (UPDRS) part 3 score was similar. Additionally, the reduced exercise group reported more motor and non-motor aggravation than the sustained exercise group, despite lack of significant difference in the UPDRS part 3 score.
The COVID-19 pandemic had a clear impact on exercise and subjective symptoms in PD patients, with reduced exercise being related to a subjective increase in both motor and non-motor symptoms of PD. Maintaining exercise should therefore be emphasized even in situations like the COVID-19 pandemic.
2019 年冠状病毒病（COVID-19）大流行扰乱了帕金森病（PD）患者的日常生活，但尚未说明其对临床的影响。在这项研究中，我们调查了 COVID-19 大流行期间 PD 患者的身体活动变化及其随后的临床症状。
我们招募了能够独立行走且于 2019 年 12 月至 2020 年 1 月（基线）和 2020 年 5 月（COVID-19 危机期间的随访）期间在三星医疗中心就诊的 PD 患者，并将其分为“持续运动组”或“减少运动组”。然后，我们评估了这两组在研究期间的运动和临床特征的变化。
共招募了 100 名受试者。在 COVID-19 大流行期间，运动量、持续时间和频率均减少。进行室内单人运动的患者人数减少，而不运动的患者人数增加。尽管统一帕金森病评定量表（UPDRS）第 3 部分评分相似，但有三分之一的患者报告说运动和非运动特征均有主观恶化。此外，与持续运动组相比，减少运动组报告的运动和非运动恶化更多，尽管 UPDRS 第 3 部分评分无明显差异。
COVID-19 大流行对 PD 患者的运动和主观症状产生了明显影响，运动量减少与 PD 的运动和非运动症状的主观增加有关。因此，即使在 COVID-19 大流行等情况下，也应强调保持运动。
