Mostafa Diana, A Alaizari Nader, M AlOtaibi Shaden, Ahmed Aldosari Najla, Rabie Al-Anazi Jamilah, S Alsughayer Rawa, M AlFayir Hadeel, S AlHarthi Mona, H AlAnazi Maram
Departement of Clinical Periodontology, Alexandria University, Alexandria, EGY.
Department of Oral Medicine and Diagnostic Sciences, Vision Colleges for Dentistry and Nursing, Riyadh, SAU.
Cureus. 2023 Feb 23;15(2):e35345. doi: 10.7759/cureus.35345. eCollection 2023 Feb.
Introduction Gingival pigmentation is mainly physiological due to the production of melanin. This study aimed to evaluate the effectiveness of a microneedling technique using topical ascorbic acid in treating gingival hyperpigmentation. Methods A case-series study was established, and 16 out of 42 participants enrolled in this study according to the inclusion and exclusion criteria. A microneedling technique was performed using a Dermapen instrument, followed by the topical application of ascorbic acid on the pigmented gingiva. Variations in the Dummett oral pigmentation index (DOPI) and Hedin melanin index (HMI) scores were considered for each patient. A one-month follow-up was conducted on all patients. Results All the reported cases demonstrated noticeable improvement at the end of the sessions. Moreover, seven patients showed complete depigmentation of the gingiva. Analysis using paired T-tests showed a statistically significant lower post-treatment DOPI score with a mean difference of 1.8 ± 0.7, 95% CI: 0.17-1.49. Similarly, the HMI score was lower post-treatment with a mean difference of 3.1 ± 0.7, 95% CI: 2.74-3.50. Conclusions Microneedling combined with topical ascorbic acid is a novel, non-invasive dental technique that can effectively treat gingival hyperpigmentation.
牙龈色素沉着主要是由于黑色素产生所致的生理性现象。本研究旨在评估使用局部应用抗坏血酸的微针技术治疗牙龈色素沉着过度的有效性。方法：开展一项病例系列研究，根据纳入和排除标准，42名参与者中有16名被纳入本研究。使用 Dermapen 仪器进行微针技术操作，随后在色素沉着的牙龈上局部应用抗坏血酸。考虑每位患者的达米特口腔色素沉着指数（DOPI）和赫丁黑色素指数（HMI）评分的变化。对所有患者进行为期一个月的随访。结果：所有报告的病例在疗程结束时均显示出明显改善。此外，7名患者牙龈完全脱色。使用配对 t 检验分析显示，治疗后 DOPI 评分在统计学上显著降低，平均差异为1.8±0.7，95%置信区间：0.17 - 1.49。同样，治疗后 HMI 评分较低，平均差异为3.1±0.7，95%置信区间：2.74 - 3.50。结论：微针联合局部应用抗坏血酸是一种新型的、非侵入性的牙科技术，可有效治疗牙龈色素沉着过度。
