Kent T A, Preskorn S H, Glotzbach R K, Irwin G H
Biol Psychiatry. 1986 May;21(5-6):483-91. doi: 10.1016/0006-3223(86)90190-3.
The cerebromicrocirculation in the tetrabenzaine (TBZ) model of depression has been found to be abnormal with respect to (1) responsiveness of cerebral blood flow to increases in arterial CO2 content and (2) the effective permeability of the blood-brain barrier to water. Development of these abnormalities temporally paralleled the behavioral disturbances and catecholamine depletion induced by TBZ. These TBZ-induced changes occurred globally throughout the brain, being apparent in the forebrain, cerebellum, and medulla-pons. Pretreatment with the antidepressant amitriptyline prevented both behavioral and physiological effects of TBZ, whereas amitriptyline administered after TBZ was less effective. The results suggest that an important action of tricyclic antidepressants may be cerebromicrocirculatory effects.
在丁苯那嗪（TBZ）诱导的抑郁症模型中，已发现脑微循环存在异常，具体表现为：（1）脑血流量对动脉血二氧化碳含量增加的反应性；（2）血脑屏障对水的有效通透性。这些异常的发展在时间上与TBZ诱导的行为障碍和儿茶酚胺耗竭相平行。这些由TBZ诱导的变化在全脑普遍存在，在前脑、小脑和延髓-脑桥中都很明显。用抗抑郁药阿米替林预处理可预防TBZ的行为和生理效应，而在TBZ给药后给予阿米替林则效果较差。结果表明，三环类抗抑郁药的一个重要作用可能是对脑微循环的影响。
