Sarmento A, Albino-Teixeira A, Azevedo I
Laboratório de Farmacologia, Faculdade de Medicina do Porto, Portugal.
Eur J Pharmacol. 1990 Jan 25;176(1):69-74. doi: 10.1016/0014-2999(90)90133-q.
Amitriptyline is known to increase the permeability of the blood-brain barrier but the morphological basis of this increase has not been studied. As catecholamines can influence pinocytosis in dog peripheral blood vessels, the effect of amitriptyline on the pinocytotic activity of blood brain microvessels was studied. Amitriptyline, 34 mg.kg-1 i.p., was injected to rats and the parietal cortex of control and treated animals was prepared for ultrastructural study. Pinocytotic vesicles in endothelial cells were quantified. Amitriptyline significantly increased the density of pinocytotic vesicles in capillary endothelial cells. No other morphological changes occurred after amitriptyline treatment. We conclude that the increase in blood-brain barrier permeability due to amitriptyline may be ascribed at least in part to an increase of pinocytotic activity in brain capillary endothelial cells.
已知阿米替林可增加血脑屏障的通透性，但这种增加的形态学基础尚未得到研究。由于儿茶酚胺可影响犬外周血管的胞饮作用，因此研究了阿米替林对血脑微血管胞饮活性的影响。将34mg.kg-1的阿米替林腹腔注射给大鼠，并制备对照动物和处理动物的顶叶皮质用于超微结构研究。对内皮细胞中的胞饮小泡进行定量。阿米替林显著增加了毛细血管内皮细胞中胞饮小泡的密度。阿米替林治疗后未出现其他形态学变化。我们得出结论，阿米替林导致的血脑屏障通透性增加可能至少部分归因于脑毛细血管内皮细胞胞饮活性的增加。
