• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

β受体阻滞剂时代婴幼儿复杂性血管瘤手术切除适应证：单中心回顾性队列研究经验。

Indications for surgical resection of complicated infantile hemangiomas in the β-blocker's era: a single-institution experience from a retrospective cohort study.

机构信息

Department of Paediatric and Adolescent Surgery.

Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Int J Surg. 2023 Apr 1;109(4):829-840. doi: 10.1097/JS9.0000000000000324.

DOI:10.1097/JS9.0000000000000324
PMID:36974689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10389552/
Abstract

BACKGROUND AND OBJECTIVES

This study aims to review how the introduction of propranolol as the primary treatment option for children with infantile hemangiomas (IHs) has affected the use of other treatment options at our institution and to determine the indications for surgical treatment of children with IHs in the propranolol era.

PATIENTS AND METHODS

The authors conducted a single-center, noncompeting, historical/retrospective cohort study to review all cases referred to the institution for IH evaluation from 2005 to 2020. The authors analyzed the complete charts of patients who received surgery from 2011 to 2020 and evaluated the reasons for each surgical intervention. Detailed descriptive statistics are provided. Logistic regression analysis and Pearson's χ2 -test were applied.

RESULTS

During the study period, 592 children received treatment. From 2011, oral propranolol ( n =268; 74%) and surgery ( n =95; 26%) were the only treatments of choice for complicated IH cases. A significant decrease in the frequency of surgical treatment was observed ( P =0.01). The authors identified four main indications for surgical treatment: (1) patients with ulceration and IH size appropriate for surgical resection (15%); (2) patients whose parents preferred surgical treatment (19%); (3) patients who presented late and underwent surgery before the age of three (29%); and (4) patients with sequelae after IH involution and excision after the third year of life (37%).

CONCLUSIONS

Despite the significant decrease in the need for surgical treatment of children with IHs since the introduction of propranolol, there are still several clear indications for treating IH cases where surgery plays a crucial role.

摘要

背景与目的

本研究旨在回顾普萘洛尔作为儿童血管瘤（IHs）主要治疗选择的引入如何影响本机构其他治疗选择的应用，并确定普萘洛尔时代儿童 IH 手术治疗的适应证。

患者与方法

作者进行了一项单中心、非竞争性、历史性/回顾性队列研究，以回顾 2005 年至 2020 年期间机构所有转诊进行 IH 评估的病例。作者分析了 2011 年至 2020 年接受手术的患者的完整图表，并评估了每次手术干预的原因。提供详细的描述性统计数据。应用逻辑回归分析和 Pearson χ2检验。

结果

在研究期间，592 名儿童接受了治疗。从 2011 年开始，口服普萘洛尔（n=268；74%）和手术（n=95；26%）是复杂 IH 病例的唯一选择治疗方法。手术治疗的频率显著下降（P=0.01）。作者确定了手术治疗的四个主要适应证：（1）溃疡和 IH 大小适合手术切除的患者（15%）；（2）父母更喜欢手术治疗的患者（19%）；（3）就诊较晚且在三岁前进行手术的患者（29%）；和（4）IH 消退后出现后遗症并在三岁后切除的患者（37%）。

结论

尽管自普萘洛尔引入以来，儿童 IH 手术治疗的需求显著减少，但仍有几个明确的适应证需要手术治疗，手术在这些适应证中起着至关重要的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/3c2fbcc7e64d/js9-109-0829-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/a77b32776997/js9-109-0829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/856029f082dd/js9-109-0829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/45e387ddc7ac/js9-109-0829-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/7208c911ab03/js9-109-0829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/51272a13dbc3/js9-109-0829-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/92059bac2300/js9-109-0829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/987b14e30796/js9-109-0829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/9ce0ba3df547/js9-109-0829-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/25690f5d1cd4/js9-109-0829-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/6db0a527a78b/js9-109-0829-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/53954b5976d0/js9-109-0829-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/3c2fbcc7e64d/js9-109-0829-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/a77b32776997/js9-109-0829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/856029f082dd/js9-109-0829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/45e387ddc7ac/js9-109-0829-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/7208c911ab03/js9-109-0829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/51272a13dbc3/js9-109-0829-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/92059bac2300/js9-109-0829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/987b14e30796/js9-109-0829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/9ce0ba3df547/js9-109-0829-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/25690f5d1cd4/js9-109-0829-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/6db0a527a78b/js9-109-0829-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/53954b5976d0/js9-109-0829-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef03/10389552/3c2fbcc7e64d/js9-109-0829-g012.jpg

相似文献

1
Indications for surgical resection of complicated infantile hemangiomas in the β-blocker's era: a single-institution experience from a retrospective cohort study.β受体阻滞剂时代婴幼儿复杂性血管瘤手术切除适应证：单中心回顾性队列研究经验。
Int J Surg. 2023 Apr 1;109(4):829-840. doi: 10.1097/JS9.0000000000000324.
2
Clinical and economic impact of surgery for treating infantile hemangiomas in the era of propranolol: overview of single-center experience from La Paz Hospital, Madrid.普萘洛尔时代治疗婴幼儿血管瘤手术的临床和经济影响：马德里拉帕兹医院单中心经验概述。
Eur J Pediatr. 2019 Jan;178(1):1-6. doi: 10.1007/s00431-018-3290-z. Epub 2018 Nov 12.
3
A commentary on 'Indications for surgical resection of complicated infantile hemangiomas in the β-blocker's era: a single-institution experience from a retrospective cohort study'.关于“β受体阻滞剂时代复杂婴儿血管瘤手术切除的指征：一项回顾性队列研究的单机构经验”的述评
Int J Surg. 2023 Dec 1;109(12):4389-4390. doi: 10.1097/JS9.0000000000000740.
4
Surgical resection of infantile hemangiomas following medical treatment with propranolol versus corticosteroids.普萘洛尔与皮质类固醇药物治疗后婴儿血管瘤的手术切除
J Pediatr Surg. 2019 Apr;54(4):740-743. doi: 10.1016/j.jpedsurg.2018.08.001. Epub 2018 Sep 5.
5
Predictors of poor response to oral propranolol in infantile hemangiomas.婴儿血管瘤口服普萘洛尔治疗反应不佳的预测因素。
Arch Pediatr. 2023 Oct;30(7):455-457. doi: 10.1016/j.arcped.2023.06.004. Epub 2023 Jun 30.
6
Use of propranolol for the treatment infantile hemangiomas in the maxillofacial region.应用普萘洛尔治疗颌面部婴幼儿血管瘤。
Int J Oral Maxillofac Surg. 2013 Jul;42(7):863-7. doi: 10.1016/j.ijom.2013.03.015. Epub 2013 Apr 22.
7
A further experience of propranolol for severe infantile hemangiomas of the face: an observational study.普萘洛尔治疗重度面部婴儿血管瘤的进一步经验：一项观察性研究。
Dermatol Ther. 2014 Jul-Aug;27(4):198-202. doi: 10.1111/dth.12116. Epub 2014 Feb 18.
8
Propranolol and infantile hemangiomas: Outcome from a tricentric study.普萘洛尔与婴儿血管瘤：一项三中心研究的结果
J Plast Reconstr Aesthet Surg. 2023 Jan;76:57-59. doi: 10.1016/j.bjps.2022.11.016. Epub 2022 Nov 23.
9
Surgical treatment outcomes of infantile hemangioma in children: Does prior medical treatment matter.儿童婴幼儿血管瘤的手术治疗结果：先前的药物治疗有影响吗？
Pediatr Dermatol. 2018 Nov;35(6):e418-e419. doi: 10.1111/pde.13658. Epub 2018 Sep 6.
10
Propranolol therapy for infantile hemangioma: our experience.普萘洛尔治疗婴儿血管瘤：我们的经验。
Drug Des Devel Ther. 2017 May 8;11:1401-1408. doi: 10.2147/DDDT.S134808. eCollection 2017.

引用本文的文献

1
Surgical Resection of Vascular Anomalies of the Upper Extremity-An Observational Study.上肢血管畸形的手术切除——一项观察性研究
J Clin Med. 2025 Mar 13;14(6):1930. doi: 10.3390/jcm14061930.
2
Paediatric Head and Neck Hemangiomas: Scopes, Challenges and Outcome of Surgical Management.小儿头颈部血管瘤：外科治疗的范围、挑战及结果
Indian J Otolaryngol Head Neck Surg. 2025 Jan;77(1):325-333. doi: 10.1007/s12070-024-05180-y. Epub 2024 Nov 13.