Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim 61231, Germany.
Hubrecht Institute-KNAW and Utrecht University Medical Center, Utrecht 3584 CT, The Netherlands.
Dis Model Mech. 2023 May 1;16(5). doi: 10.1242/dmm.050147. Epub 2023 Mar 28.
Didier Stainier is Director of the Department of Developmental Genetics at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany. He became acquainted with the zebrafish model as a PhD student in Walter Gilbert's lab at Harvard, which motivated him to champion the use of this powerful model organism to study heart development as a postdoctoral fellow with Mark Fishman at Massachusetts General Hospital. Although his scientific focus has expanded significantly since then, zebrafish modelling and heart development and regeneration remain key topics in his research. The developmental biology and zebrafish modelling communities have embraced him as an inspiring mentor and advocate for basic research. Jeroen Bakkers is a group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and Professor of Molecular Cardiogenetics at the University Medical Center Utrecht, The Netherlands. Jeroen did hid PhD with Herman Spaink at Leiden University, The Netherlands. A short visit to Massachusetts Institute of Technology during his doctoral training introduced him to the zebrafish model, which he applied to his PhD project. Zebrafish development remained the focus of his career, including during his postdoctoral training in the lab of Matthias Hammerschmidt at the Max Planck Institute of Immunology and Epigenetics in Freiburg and in his own lab at the Hubrecht Institute, where his group uses this powerful model organism to investigate cardiac development, disease and regeneration. Jeroen and Didier met up at a recent conference to talk about their shared interest in cardiac regeneration, a zebrafish mutant with a curious name and Didier's commitment to mentorship.
迪迪埃·斯坦尼尔(Didier Stainier)是德国巴特瑙海姆马克斯·普朗克心肺研究所发育遗传学系主任。他在哈佛的沃尔特·吉尔伯特(Walter Gilbert)实验室攻读博士学位时,开始熟悉斑马鱼模型,并在马萨诸塞州总医院与马克·菲什曼(Mark Fishman)一起做博士后时,就开始倡导使用这种强大的模式生物来研究心脏发育。尽管从那时起,他的科学重点已经大大扩展,但斑马鱼模型和心脏发育与再生仍然是他研究的关键主题。发育生物学和斑马鱼模型社区将他视为鼓舞人心的导师和基础研究的拥护者。杰罗恩·巴克斯(Jeroen Bakkers)是荷兰乌得勒支大学医学中心发育生物学和干细胞研究中心的组长,也是分子心脏遗传学教授。杰罗恩在荷兰莱顿大学完成了他的博士学位,在博士培训期间,他在马萨诸塞理工学院的一次短暂访问使他接触到了斑马鱼模型,他将其应用到了博士项目中。斑马鱼的发育仍然是他职业生涯的重点,包括在马克斯·普朗克免疫与表观遗传学研究所的马蒂亚斯·哈默施密特(Matthias Hammerschmidt)实验室以及在他自己的赫布里特研究所的实验室进行博士后培训期间,他的团队在该实验室使用这种强大的模式生物来研究心脏发育、疾病和再生。杰罗恩和迪迪埃在最近的一次会议上会面,讨论了他们对心脏再生的共同兴趣、一个名字很奇怪的斑马鱼突变体,以及迪迪埃对指导的承诺。