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Live imaging of adult zebrafish cardiomyocyte proliferation ex vivo.成年斑马鱼心肌细胞增殖的活体成像。
Development. 2021 Sep 15;148(18). doi: 10.1242/dev.199740. Epub 2021 Sep 13.
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Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.克洛什(Cloche)是一个 bHLH-PAS 转录因子,它驱动造血血管的特化。
Nature. 2016 Jul 14;535(7611):294-8. doi: 10.1038/nature18614.
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Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies.斑马鱼中的条件性靶向细胞消融:再生研究的新工具。
Dev Dyn. 2007 Apr;236(4):1025-35. doi: 10.1002/dvdy.21100.
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Heart regeneration in zebrafish.斑马鱼的心脏再生
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Cell-autonomous and non-autonomous requirements for the zebrafish gene cloche in hematopoiesis.斑马鱼基因cloche在造血过程中的细胞自主和非自主需求。
Development. 1999 Jun;126(12):2643-51. doi: 10.1242/dev.126.12.2643.
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Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo.影响斑马鱼胚胎心血管系统形成和功能的突变
Development. 1996 Dec;123:285-92. doi: 10.1242/dev.123.1.285.
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The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.在斑马鱼(Danio rerio)发育过程中具有独特且重要功能的基因的鉴定。
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Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages.克洛什是一种早期起作用的斑马鱼基因,内皮细胞谱系和造血细胞谱系都需要它。
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揭开神秘面纱:杰罗恩·贝克采访迪迪埃·斯坦尼尔。

Lifting the cloche: Jeroen Bakkers interviews Didier Stainier.

机构信息

Max Planck Institute for Heart and Lung Research, Department of Developmental Genetics, Bad Nauheim 61231, Germany.

Hubrecht Institute-KNAW and Utrecht University Medical Center, Utrecht 3584 CT, The Netherlands.

出版信息

Dis Model Mech. 2023 May 1;16(5). doi: 10.1242/dmm.050147. Epub 2023 Mar 28.

DOI:10.1242/dmm.050147
PMID:36974941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10110420/
Abstract

Didier Stainier is Director of the Department of Developmental Genetics at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany. He became acquainted with the zebrafish model as a PhD student in Walter Gilbert's lab at Harvard, which motivated him to champion the use of this powerful model organism to study heart development as a postdoctoral fellow with Mark Fishman at Massachusetts General Hospital. Although his scientific focus has expanded significantly since then, zebrafish modelling and heart development and regeneration remain key topics in his research. The developmental biology and zebrafish modelling communities have embraced him as an inspiring mentor and advocate for basic research. Jeroen Bakkers is a group leader at the Hubrecht Institute for Developmental Biology and Stem Cell Research and Professor of Molecular Cardiogenetics at the University Medical Center Utrecht, The Netherlands. Jeroen did hid PhD with Herman Spaink at Leiden University, The Netherlands. A short visit to Massachusetts Institute of Technology during his doctoral training introduced him to the zebrafish model, which he applied to his PhD project. Zebrafish development remained the focus of his career, including during his postdoctoral training in the lab of Matthias Hammerschmidt at the Max Planck Institute of Immunology and Epigenetics in Freiburg and in his own lab at the Hubrecht Institute, where his group uses this powerful model organism to investigate cardiac development, disease and regeneration. Jeroen and Didier met up at a recent conference to talk about their shared interest in cardiac regeneration, a zebrafish mutant with a curious name and Didier's commitment to mentorship.

摘要

迪迪埃·斯坦尼尔(Didier Stainier)是德国巴特瑙海姆马克斯·普朗克心肺研究所发育遗传学系主任。他在哈佛的沃尔特·吉尔伯特(Walter Gilbert)实验室攻读博士学位时,开始熟悉斑马鱼模型,并在马萨诸塞州总医院与马克·菲什曼(Mark Fishman)一起做博士后时,就开始倡导使用这种强大的模式生物来研究心脏发育。尽管从那时起,他的科学重点已经大大扩展,但斑马鱼模型和心脏发育与再生仍然是他研究的关键主题。发育生物学和斑马鱼模型社区将他视为鼓舞人心的导师和基础研究的拥护者。杰罗恩·巴克斯(Jeroen Bakkers)是荷兰乌得勒支大学医学中心发育生物学和干细胞研究中心的组长,也是分子心脏遗传学教授。杰罗恩在荷兰莱顿大学完成了他的博士学位,在博士培训期间,他在马萨诸塞理工学院的一次短暂访问使他接触到了斑马鱼模型,他将其应用到了博士项目中。斑马鱼的发育仍然是他职业生涯的重点,包括在马克斯·普朗克免疫与表观遗传学研究所的马蒂亚斯·哈默施密特(Matthias Hammerschmidt)实验室以及在他自己的赫布里特研究所的实验室进行博士后培训期间,他的团队在该实验室使用这种强大的模式生物来研究心脏发育、疾病和再生。杰罗恩和迪迪埃在最近的一次会议上会面,讨论了他们对心脏再生的共同兴趣、一个名字很奇怪的斑马鱼突变体,以及迪迪埃对指导的承诺。