Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Plumas County Public Health Agency, Quincy, California, USA.
Am J Ind Med. 2023 Jul;66(7):543-553. doi: 10.1002/ajim.23476. Epub 2023 Mar 28.
While all forms of asbestos have been determined to be carcinogenic to humans by the International Agency for Research on Cancer (IARC) as well as other authoritative bodies, the relative carcinogenic potency of chrysotile continues to be argued, largely in the context of toxic tort litigation. Relatively few epidemiologic studies have investigated only a single form of asbestos; however, one study that included an asbestos textile plant located in Marshville, North Carolina that processed chrysotile asbestos was used by the United States Environmental Protection Agency (EPA) in 2020 to help inform the agency's chrysotile asbestos risk assessment. During the EPA proceedings toxic tort defense consultants submitted comments to the EPA docket and made public presentations asserting that the Marshville plant had processed amphibole asbestos types and should not be used for the chrysotile risk assessment. A detailed evaluation of defense consultant assertions and supporting information and a full assessment of the available information concerning asbestos types used at the Marshville plant was undertaken. The preponderance of evidence continues to support the conclusion that neither amosite nor crocidolite were likely to have been processed in the Marshville textile plant. Defense consultants' assertions about chrysotile use are not supported by the preponderance of evidence and constitute an example of manipulation of information to cast uncertainty and doubt rather than to seek truth and contribute to the body of scientific evidence.
虽然国际癌症研究机构(IARC)和其他权威机构已经确定所有形式的石棉对人类都具有致癌性,但温石棉的相对致癌效力仍存在争议,主要是在毒理侵权诉讼的背景下。相对较少的流行病学研究仅调查了一种形式的石棉;然而,美国环境保护署(EPA)在 2020 年使用了一项包括位于北卡罗来纳州马什维尔的一家加工温石棉的石棉纺织厂的研究,以帮助为该机构的温石棉石棉风险评估提供信息。在 EPA 的诉讼程序中,毒理侵权辩护顾问向 EPA 案件提交了评论,并公开陈述称,马什维尔工厂加工了闪石石棉类型,不应将其用于温石棉风险评估。对辩护顾问的断言和支持信息进行了详细评估,并对马什维尔工厂使用的石棉类型的可用信息进行了全面评估。证据的优势继续支持这样的结论,即在马什维尔纺织厂不太可能加工铁石棉或青石棉。辩护顾问关于温石棉使用的断言没有得到优势证据的支持,这是操纵信息以制造不确定性和怀疑而不是寻求真相并为科学证据体做出贡献的一个例子。