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[用二氢睾酮处理的大鼠雄性生殖系统器官的抑制素活性]

[Inhibin activity of the organs of the male reproductive system in rats treated with dihydrotestosterone].

作者信息

Gladkova A I

出版信息

Biull Eksp Biol Med. 1986 Apr;101(4):487-8.

PMID:3697501
Abstract

The content of protein hormone, inhibin, in the rat testis and prostate has been studied on preadolescent female mice. Both organs were characterized by a certain inhibin activity, it being higher in the prostate. A single injection of 25 mu kg dihydrotestosterone (DHT) to rats has been followed by the increase in testicular and prostate mass, elevation of 17 alpha-hydroxyprogesterone and testosterone levels in peripheral blood, and a slight rise in inhibin testicular activity, with the lack of these changes in the prostate. The detection of inhibin in the prostate confirms possible direct link of the organ with the pituitary body. DHT effect on spermatogenesis has been but insignificantly related to FSH depression.

摘要

已在青春期前雌性小鼠身上研究了大鼠睾丸和前列腺中蛋白质激素抑制素的含量。这两个器官都具有一定的抑制素活性,前列腺中的活性更高。给大鼠单次注射25微克二氢睾酮(DHT)后,睾丸和前列腺重量增加,外周血中17α-羟孕酮和睾酮水平升高,睾丸抑制素活性略有上升,而前列腺中则没有这些变化。在前列腺中检测到抑制素证实了该器官与垂体可能存在直接联系。DHT对精子发生的影响与促卵泡激素(FSH)的降低关系不大。

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