Pages G, Bouley G, Dubreuil A, Ameille J, Guillon F
Bull Eur Physiopathol Respir. 1986 Jan-Feb;22(1):9-14.
A study of the effects of inhaled hair-spray was performed on 118 specific pathogen free male Wistar rats (71 test animals and 47 controls). Rats were exposed for 5 min, three times a day, five days per week, during one to eight weeks, in two plexiglas chambers, one for controls and one for test animals. The chambers were 20 1 in size, but only the noses of the animals were exposed to ambiant air or to a hair-spray aerosol polluted atmosphere. In the test chamber, the hair-spray was aerosolized for 30 s at the beginning of each exposure, using about 30 g of nebulized product. This hair-spray amount was high, although non-lethal (70% of DL0, 45% of DL50 and 26% of DL100). The hair-spray exposed rats exhibited significant modifications in the antixenic defence mechanisms of their respiratory system: diminished ciliary activity of the tracheal epithelium (-26%), increased number of harvested pulmonary macrophages (+52%), but decreased phagocytic ability of these cells (-8%). However we did not observe histologic differences in the respiratory system of exposed and control rats.
对118只无特定病原体的雄性Wistar大鼠（71只试验动物和47只对照动物）进行了吸入发胶影响的研究。大鼠在两个有机玻璃舱中暴露，一个用于对照动物，一个用于试验动物，暴露时间为5分钟，每天3次，每周5天，持续1至8周。舱体大小为20升，但动物仅鼻子暴露于周围空气或受发胶气雾剂污染的大气中。在试验舱中，每次暴露开始时，使用约30克雾化产品将发胶雾化30秒。该发胶用量虽高，但无致死性（LD0的70%、LD50的45%和LD100的26%）。暴露于发胶的大鼠呼吸系统的抗异物防御机制出现显著变化：气管上皮的纤毛活性降低（-26%），肺巨噬细胞收获数量增加（+52%），但这些细胞的吞噬能力下降（-8%）。然而，我们未观察到暴露大鼠和对照大鼠呼吸系统的组织学差异。
