Bouley G, Dubreuil A, Jouany J M, Boudène C
Bull Eur Physiopathol Respir. 1981 Nov-Dec;17(6):903-10.
Since the use of plastic materials, a change in the pathology of fire victims has been observed. We studied the effects of a single short-term inhalation (30 min) of a sub-lethal dose of polypropylene pyrolysis products (one LD-0). Including control and test animals, 66 rats and 112 mice were used. The exposure provoked disturbances in the antixenic defense mechanisms of the respiratory system, chiefly in tracheo-bronchial defenses, since we observed a lowering of ciliary activity of 35 to 78% in test animals exposed a few hours before, compared with the controls. These changes provoked a significant increase in death-rate of test animals, following experimental airborne infection by Klebsiella pneumoniae. The combustion products of polypropylene plastic materials did not contain hydrocyanic acid nor hydrochloric acid, and neither the temperature of the inhaled air, nor the concentration of carbon monoxide could explain these effects. On the contrary, we can suspect the well known irritative properties of aldehyde compounds formed during smoldering combustion of polypropylene.
自从使用塑料材料以来，人们观察到火灾受害者的病理学发生了变化。我们研究了单次短期吸入（30分钟）亚致死剂量的聚丙烯热解产物（一个LD-0）的影响。包括对照动物和试验动物在内，共使用了66只大鼠和112只小鼠。这种暴露引发了呼吸系统抗排斥防御机制的紊乱，主要是气管-支气管防御方面的紊乱，因为我们观察到，与对照组相比，在几小时前暴露的试验动物中，纤毛活动降低了35%至78%。这些变化导致试验动物在经肺炎克雷伯菌进行实验性空气传播感染后死亡率显著增加。聚丙烯塑料材料的燃烧产物不含氢氰酸和盐酸，吸入空气的温度和一氧化碳浓度都无法解释这些影响。相反，我们可以怀疑聚丙烯阴燃过程中形成的醛类化合物具有众所周知的刺激性。
