Aldridge Jamie H R
Jamie H. R. Aldridge is a medical science liaison for argenx USA, Inc., in Boston, Mass., and practices at Moses H. Cone Memorial Hospital in Greensboro, N.C. The author has disclosed no potential conflicts of interest, financial or otherwise.
JAAPA. 2023 Apr 1;36(4):39-41. doi: 10.1097/01.JAA.0000921280.56648.da.
Clostridium botulinum is a Gram-positive bacterium that produces one of the most deadly chemodenervating toxins in the world. To date, six distinct neurotoxins are available for prescription use in the United States. Decades of data across aesthetic therapeutic areas and therapeutic disease states support the safety and efficacy of C. botulinum, providing good symptom management and improved quality of life in appropriately chosen patients. Unfortunately, many clinicians are slow to progress patients to toxin therapy from more conservative measures, and others wrongly interchange the products despite characteristics unique to each. Commensurate with an improved understanding of the complex pharmacology and clinical implications of botulinum neurotoxins is the importance for clinicians to appropriately identify, educate, refer, and/or treat candidate patients. This article provides an overview of the history, mechanism of action, differentiation, indications, and uses for botulinum neurotoxins.
肉毒杆菌是一种革兰氏阳性菌，能产生世界上最致命的化学去神经毒素之一。迄今为止，美国有六种不同的神经毒素可供处方使用。在美容治疗领域和治疗疾病状态方面数十年的数据支持了肉毒杆菌的安全性和有效性，在适当选择的患者中能提供良好的症状管理并改善生活质量。不幸的是，许多临床医生从更保守的措施转向毒素治疗的进展缓慢，还有一些人尽管每种产品都有独特的特性，但仍错误地互换使用。随着对肉毒杆菌神经毒素复杂药理学和临床意义的认识不断提高，临床医生正确识别、教育、转诊和/或治疗候选患者变得至关重要。本文概述了肉毒杆菌神经毒素的历史、作用机制、鉴别、适应症和用途。
