Departments of Pediatrics and Genetics, Albert Einstein College of Medicine, New York, New York.
Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Clin Cancer Res. 2023 Jun 1;29(11):2017-2019. doi: 10.1158/1078-0432.CCR-23-0390.
The novel use of blood-based biospecimens from a retrospective cohort of 50 patients with osteosarcoma was recently studied. The potential clinical utility of sorting cell-free DNA by fragment size was defined, with shorter tumor-specific DNA enrichment providing prognostic value and allowing for streamlined molecular profiling of circulating tumor material. See related article by Udomruk et al., p. 2085.
最近研究了一种新颖的方法，即利用 50 名骨肉瘤患者回顾性队列的基于血液的生物样本。通过片段大小对无细胞 DNA 进行分类的潜在临床应用得到了定义，较短的肿瘤特异性 DNA 富集提供了预后价值，并允许对循环肿瘤物质进行简化的分子分析。见 Udomruk 等人的相关文章，第 2085 页。
