Department of Orthopedics, Yidu Central Hospital of Weifang, Qingzhou, China.
Eur Rev Med Pharmacol Sci. 2018 Apr;22(8):2310-2314. doi: 10.26355/eurrev_201804_14820.
To investigate the potential role of Long non-coding RNA (lncRNA) FER1L4 in the diagnosis and prognostic assessment of osteosarcoma.
LncRNA FER1L4 expression in osteosarcoma samples was detected by real-time PCR. The Kaplan-Meier method was used to analyze the relationship between lncRNA FER1L4 expression and the survival time of patients.
LncRNA FER1L4 expression was decreased in osteosarcoma samples. LncRNA FER1L4 was not related to the gender and age of patients, but was significantly associated with disease stage, metastasis, and tumor differentiation.
Low-expression of lncRNA FER1L4 might be a prognostic marker in osteosarcoma.
探讨长链非编码 RNA（lncRNA）FER1L4 在骨肉瘤诊断和预后评估中的作用。
采用实时 PCR 检测骨肉瘤组织中 lncRNA FER1L4 的表达。采用 Kaplan-Meier 法分析 lncRNA FER1L4 表达与患者生存时间的关系。
lncRNA FER1L4 在骨肉瘤组织中表达下调。lncRNA FER1L4 与患者的性别和年龄无关，但与疾病分期、转移和肿瘤分化显著相关。
lncRNA FER1L4 低表达可能是骨肉瘤的预后标志物。
