原发性干燥综合征中炎症标志物与高血压风险的关系：一项回顾性队列研究。

Relationships between inflammation markers and the risk of hypertension in primary Sjögren's syndrome: A retrospective cohort study.

机构信息

Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

Department of Geriatrics, North Sichuan Medical College, Nanchong, Sichuan, China.

出版信息

Mod Rheumatol. 2024 Feb 26;34(2):369-375. doi: 10.1093/mr/road032.

DOI:10.1093/mr/road032

PMID:36976576

Abstract

OBJECTIVES

The association of inflammation markers with hypertension (HTN) in primary Sjögren's syndrome (pSS) remains controversial. We aimed to investigate whether inflammation markers are at increased risk of developing HTN in pSS patients.

METHODS

A retrospective cohort study included pSS patients (n = 380) between May 2011 and May 2020 from the Third People's Hospital of Chengdu. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) of the potential inflammation markers for pSS-HTN. Subsequently, the dose-response relationships were also used.

RESULTS

Out of 380 pSS patients, 171 (45%) developed HTN, and the median follow-up period was 4.16 years. Univariable Cox regression analysis showed that the erythrocyte sedimentation rate (ESR) and neutrophils were significantly associated with the incident HTN (P < 0.05). After adjustment for covariates, this association between ESR (adjusted HR 1.017, 95%CI: 1.005-1.027, P = .003), neutrophils (adjusted HR 1.356, 95%CI: 1.113-1.653, P = .003), and HTN remained significant. The dose-effect relationship was also found between ESR, neutrophils, and HTN (P = .001).

CONCLUSIONS

Inflammation markers may play an important role in the incident HTN in pSS.

摘要

目的

炎症标志物与原发性干燥综合征（pSS）患者高血压（HTN）的相关性仍存在争议。本研究旨在探讨炎症标志物是否会增加 pSS 患者发生 HTN 的风险。

方法

本回顾性队列研究纳入了 2011 年 5 月至 2020 年 5 月期间来自成都市第三人民医院的 380 例 pSS 患者。采用多变量 Cox 回归分析评估潜在炎症标志物发生 pSS-HTN 的风险比（HR）。随后，还使用了剂量-反应关系。

结果

380 例 pSS 患者中，171 例（45%）发生了 HTN，中位随访时间为 4.16 年。单变量 Cox 回归分析显示，红细胞沉降率（ESR）和中性粒细胞与 HTN 的发生显著相关（P<0.05）。调整协变量后，ESR（调整 HR 1.017，95%CI：1.005-1.027，P=0.003）和中性粒细胞（调整 HR 1.356，95%CI：1.113-1.653，P=0.003）与 HTN 之间的相关性仍然显著。还发现 ESR、中性粒细胞与 HTN 之间存在剂量-效应关系（P=0.001）。