Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.
J Clin Hypertens (Greenwich). 2022 Aug;24(8):1026-1034. doi: 10.1111/jch.14541. Epub 2022 Jul 9.
Primary Sjögren's syndrome (pSS) patients with hypertension (pSS-HT) have a significantly increased risk of cardio-cerebrovascular events. Serum uric acid (SUA), a potential inflammatory substance, is considered to be closely related to hypertension in the general population. Our aim is to assess the association between SUA and pSS-HT. This is a retrospective cohort study. The diagnosis of pSS is based on the American European Consensus Classification criteria. Primary outcome was incident hypertension in pSS patients. Cox regression model was used to estimate the hazard ratios (HR) and 95% CI of SUA in pSS-HT. The authors also plotted Kaplan-Meier plots to assess the cumulative risk of first hypertension in patients with hyperuricemia and normal uric acid. In addition, the dose-response curve was also used to discuss the relationship between SUA and pSS-HT. Finally, three hundred and fifty-one pSS patients were enrolled from May 2011 to May 2020, of which 166 cases developed hypertension within a mean follow-up of 3.91 years. Univariate Cox regression demonstrated that SUA was associated with the onset of hypertension in pSS (HR: 1.005 95%Cl: 1.002-1.009). After adjusting for the potential risk factors, the relationship remained unchanged (HR: 1.003, 95%Cl: 1.001-1.005). Kaplan-Meier survival analysis showed a statistically significant difference of hypertension risk between hyperuricemia patients and normal uric acid patients (P = .026). There was also a significant dose-effect relationship between SUA and hypertension in pSS in dose-response model. In this study, the authors find that SUA may be closely associated with the development of hypertension in pSS, which is also confirmed by our dose-response model. Therefore, SUA could be considered in the management of pSS-HT.
原发性干燥综合征（pSS）合并高血压（pSS-HT）患者发生心脑血管事件的风险显著增加。血清尿酸（SUA）作为一种潜在的炎症物质，在普通人群中被认为与高血压密切相关。本研究旨在评估 SUA 与 pSS-HT 的相关性。这是一项回顾性队列研究。pSS 的诊断基于美国欧洲共识分类标准。主要结局是 pSS 患者发生高血压的情况。采用 Cox 回归模型估计 SUA 与 pSS-HT 之间的风险比（HR）和 95%置信区间（CI）。作者还绘制了 Kaplan-Meier 图来评估高尿酸血症和正常尿酸血症患者首次发生高血压的累积风险。此外，剂量-反应曲线也用于探讨 SUA 与 pSS-HT 之间的关系。最后，作者从 2011 年 5 月至 2020 年 5 月共纳入 351 例 pSS 患者，平均随访 3.91 年后，有 166 例发生高血压。单因素 Cox 回归表明，SUA 与 pSS 患者高血压的发生相关（HR：1.005，95%CI：1.002-1.009）。调整潜在的危险因素后，这种关系仍然不变（HR：1.003，95%CI：1.001-1.005）。Kaplan-Meier 生存分析显示，高尿酸血症患者和正常尿酸血症患者之间高血压风险存在统计学差异（P =.026）。在剂量-反应模型中，SUA 与 pSS 中的高血压也存在显著的剂量效应关系。在这项研究中，作者发现 SUA 可能与 pSS 中高血压的发生密切相关，这也被我们的剂量-反应模型所证实。因此，SUA 可在 pSS-HT 的管理中考虑。
