Harris Paul, Myers Mark H
Department of Vision Therapy, Southern College of Optometry, Memphis, TN 38104, USA.
Department of Anatomy and Neurobiology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Neurol Int. 2023 Mar 20;15(1):534-548. doi: 10.3390/neurolint15010032.
In this study, we examined visual processing within primary visual areas (V1) in normal and visually impaired individuals who exhibit significant visual symptomology due to sports-related mild traumatic brain injury (mTBI). Five spatial frequency stimuli were applied to the right, left and both eyes in order to assess the visual processing of patients with sports-related mild traumatic brain injuries who exhibited visual abnormalities, i.e., photophobia, blurriness, etc., and controls. The measurement of the left/right eye and binocular integration was accomplished via the quantification of the spectral power and visual event-related potentials. The principal results have shown that the power spectral density (PSD) measurements display a distinct loss in the alpha band-width range, which corresponded to more instances of medium-sized receptive field loss. Medium-size receptive field loss may correspond to parvocellular (p-cell) processing deprecation. Our major conclusion provides a new measurement, using PSD analysis to assess mTBI conditions from primary V1 areas. The statistical analysis demonstrated significant differences between the mTBI and control cohort in the Visual Evoked Potentials (VEP) amplitude responses and PSD measurements. Additionally, the PSD measurements were able to assess the improvement in the mTBI primary visual areas over time through rehabilitation.
在本研究中，我们检查了因运动相关轻度创伤性脑损伤（mTBI）而出现明显视觉症状的正常个体和视力受损个体的初级视觉区域（V1）内的视觉处理情况。向右眼、左眼和双眼施加了五种空间频率刺激，以评估出现视觉异常（即畏光、视力模糊等）的运动相关轻度创伤性脑损伤患者以及对照组的视觉处理情况。通过对频谱功率和视觉事件相关电位的量化来完成对左眼/右眼和双眼整合的测量。主要结果表明，功率谱密度（PSD）测量显示α带宽范围内明显降低，这对应于更多中等大小感受野丧失的情况。中等大小感受野丧失可能对应于小细胞（p细胞）处理功能衰退。我们的主要结论提供了一种新的测量方法，即使用PSD分析从初级V1区域评估mTBI情况。统计分析表明，mTBI组和对照组在视觉诱发电位（VEP）幅度反应和PSD测量方面存在显著差异。此外，PSD测量能够通过康复评估mTBI初级视觉区域随时间的改善情况。
