关于对PM暴露激活NLRP3炎性小体进行人体研究的必要性。
On the Need for Human Studies of PM Exposure Activation of the NLRP3 Inflammasome.
作者信息
Brugge Doug, Li Jianghong, Zamore Wig
机构信息
Department of Public Health Sciences, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.
Institute for Community Research, Hartford, CT 06106, USA.
出版信息
Toxics. 2023 Feb 21;11(3):202. doi: 10.3390/toxics11030202.
Abstract
Particulate matter air pollution is associated with blood inflammatory biomarkers, however, the biological pathways from exposure to periferal inflammation are not well understood. We propose that the NLRP3 inflammasome is likely stimulated by ambient particulate matter, as it is by some other particles and call for more research into this pathway.
摘要
空气中的颗粒物污染与血液中的炎症生物标志物有关，然而，从暴露于环境到外周炎症的生物学途径尚未完全了解。我们认为，NLRP3炎性小体可能像受到其他一些颗粒刺激一样，受到环境颗粒物的刺激，并呼吁对这一途径进行更多研究。
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