Haring J H, Miller G D, Davis J N
Brain Res. 1986 Mar 19;368(2):233-8. doi: 10.1016/0006-8993(86)90566-4.
Lesions of the septal region result in a significant decrease in the norepinephrine content of the area dentata. Over a period of one year, norepinephrine levels return to normal, presumably due to the proliferation of remaining locus coeruleus fibers. Unilateral lesions of the locus coeruleus produce reductions in [3H]norepinephrine uptake values of about 70% and 30% in the ipsilateral and contralateral area dentata, respectively. By 12 weeks after lesion, the noradrenergic fiber density in the contralateral area dentata is within the range of control measurements, whereas the area dentata ipsilateral to the lesion remains significantly depleted of noradrenergic fibers. At 26 weeks postlesion, no further change was observed in the noradrenergic fiber density of either area dentata. These results are interpreted in light of the hypothesis that locus coeruleus axon proliferation is induced by axotomy and represents the expansion of intact collaterals of damaged fibers.
中隔区损伤会导致齿状回区域去甲肾上腺素含量显著降低。在一年的时间里，去甲肾上腺素水平恢复正常，推测是由于剩余蓝斑纤维的增殖。蓝斑单侧损伤分别使同侧和对侧齿状回的[3H]去甲肾上腺素摄取值降低约70%和30%。损伤后12周，对侧齿状回的去甲肾上腺素能纤维密度在对照测量范围内，而损伤同侧的齿状回去甲肾上腺素能纤维仍明显减少。损伤后26周，两个齿状回区域的去甲肾上腺素能纤维密度均未观察到进一步变化。这些结果是根据以下假设来解释的：蓝斑轴突增殖是由轴突切断术诱导的，代表受损纤维完整侧支的扩张。
