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[电子烟:减少危害还是延长危害?]

[Electronic cigarettes: harm reduction or harm prolongation?].

作者信息

Hanewinkel Reiner

机构信息

Institut für Therapie- und Gesundheitsforschung, IFT-Nord gGmbH, Kiel, Deutschland.

出版信息

Pneumologie. 2023 Apr;77(4):233-238. doi: 10.1055/a-2034-6214. Epub 2023 Mar 28.

Abstract

This paper deals with the question of whether electronic cigarettes (e-cigarettes) can minimize the proven harm of smoking tobacco or may lead to a long-term harm. While the British Royal College of Physicians recommends smokers to use e-cigarettes as a substitute for tobacco products, the German Society for Pneumology and Respiratory Medicine advises smokers against using e-cigarettes. The harm reduction strategy is based on three hypotheses. Hypothesis 1: It is assumed that e-cigarettes cause less damage to health than tobacco cigarettes. Hypothesis 2: It is postulated that smokers are motivated to switch from conventional cigarettes to e-cigarettes. Hypothesis 3: It is assumed that e-cigarettes are an effective means for quitting smoking with few side effects. Although the long-term health consequences of e-cigarette use remain unknown, there is increasing evidence that e-cigarettes are toxic, harmful to cardiovascular system, respiratory health and potentially carcinogenic. Population-representative epidemiological surveys have shown that three-quarters of all current e-cigarette users in Germany smoke tobacco at the same time. In a few randomized clinical trials, e-cigarettes showed higher success rates compared to nicotine replacement products. As over-the-counter consumer products, a large number of studies have found no advantage for e-cigarettes under real conditions. In addition, e-cigarettes prolong nicotine dependence compared to nicotine replacement products. According to the current state of knowledge, the hypotheses behind the harm minimization strategy using e-cigarettes must be regarded as refuted. It therefore appears ethically problematic when doctors recommend e-cigarettes to their patients as a substitute for smoking.

摘要

本文探讨了电子烟能否将吸烟已证实的危害降至最低或是否可能导致长期危害的问题。虽然英国皇家内科医师学院建议吸烟者使用电子烟替代烟草制品,但德国肺脏与呼吸医学协会却建议吸烟者不要使用电子烟。减少危害策略基于三个假设。假设1:假定电子烟对健康造成的损害小于烟草香烟。假设2:假定吸烟者有动力从传统香烟转向电子烟。假设3:假定电子烟是一种戒烟的有效手段,且副作用很少。尽管使用电子烟的长期健康后果尚不清楚,但越来越多的证据表明电子烟有毒,对心血管系统、呼吸系统健康有害且可能致癌。具有人群代表性的流行病学调查显示,德国目前所有电子烟使用者中有四分之三同时也吸烟。在一些随机临床试验中,与尼古丁替代产品相比,电子烟显示出更高的成功率。作为非处方消费产品,大量研究发现在实际情况下电子烟并无优势。此外,与尼古丁替代产品相比,电子烟会延长尼古丁依赖。根据目前的知识水平,使用电子烟的危害最小化策略背后所依据的假设必须被视为已被推翻。因此,当医生向患者推荐电子烟作为吸烟替代品时,在伦理上似乎存在问题。

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