Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
Diabetes Metab J. 2023 May;47(3):347-355. doi: 10.4093/dmj.2022.0444. Epub 2023 Mar 29.
This study investigated the changes of fatty liver disease prevalence in general Korean population.
This study analyzed data from the Korean National Health Insurance Service from 2009 to 2017 that included individuals aged 20 years or older who had undergone a medical health examination. Fatty liver disease was assessed using the fatty liver index (FLI). The disease severity was defined by FLI cutoff, ≥30 as moderate, and ≥60 as severe fatty liver disease.
The prevalence of Korean adults aged 20 years or over with fatty liver disease (FLI ≥60) increased from 13.3% in 2009 to 15.5% in 2017 (P for trend <0.001). The increase in fatty liver disease prevalence was prominent in men (from 20.5% to 24.2%) and the young age (20 to 39 years) group (from 12.8% to 16.4%) (P for interaction <0.001). The prevalence of fatty liver disease was the highest in type 2 diabetes mellitus (T2DM, 29.6%) population compared to that of prediabetes or normoglycemia (10.0% and 21.8%) in 2017. The prevalence of fatty liver disease had statistically increased in individuals with T2DM and prediabetes (P for trend <0.001). Its prevalence increased more steeply in the young-aged population with T2DM, from 42.2% in 2009 to 60.1% in 2017. When applying a lower FLI cutoff (≥30) similar results were observed.
The prevalence of fatty liver disease in the Korean population has increased. Individuals who are young, male, and have T2DM are vulnerable to fatty liver disease.
本研究旨在调查韩国普通人群中脂肪肝疾病患病率的变化。
本研究分析了韩国国家健康保险服务 2009 年至 2017 年的数据，包括接受过医疗体检的 20 岁及以上的个体。使用脂肪肝指数（FLI）评估脂肪肝疾病。通过 FLI 截断值定义疾病严重程度，≥30 为中度，≥60 为重度脂肪肝疾病。
2009 年至 2017 年，韩国 20 岁及以上成年人中脂肪肝疾病（FLI≥60）的患病率从 13.3%增至 15.5%（趋势 P<0.001）。男性（从 20.5%增至 24.2%）和年轻（20 至 39 岁）人群中脂肪肝疾病患病率的增加更为显著（从 12.8%增至 16.4%）（交互作用 P<0.001）。2017 年，与糖尿病前期或血糖正常者（10.0%和 21.8%）相比，2 型糖尿病（T2DM）患者的脂肪肝疾病患病率最高（29.6%）。2017 年，T2DM 和糖尿病前期患者的脂肪肝疾病患病率呈统计学增加（趋势 P<0.001）。T2DM 年轻患者的患病率增加更为陡峭，从 2009 年的 42.2%增至 2017 年的 60.1%。应用较低的 FLI 截断值（≥30）时也观察到了类似的结果。
韩国人群中脂肪肝疾病的患病率有所增加。年轻、男性和患有 T2DM 的个体易患脂肪肝疾病。
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