Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Diabetes Res Clin Pract. 2024 Jun;212:111584. doi: 10.1016/j.diabres.2024.111584. Epub 2024 Feb 15.
To investigate the impact of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) on the risk of type 2 diabetes mellitus in young Korean adults.
Data were sourced from the Korean National Health Insurance Service-Health Screening Cohort, comprising adults aged 20-39 who underwent health examinations between 2009 and 2012. Participants were grouped based on the presence of MAFLD and nonalcoholic fatty liver disease (NAFLD), both individually and in combination. The categorizations included Neither-FLD, NAFLD-only, MAFLD-only, or Both-FLD. Incident diabetes was identified through claims data during the follow-up period.
Among 6,232,656 participants, 676,747 (10.8 %) had MAFLD. During a median follow-up of 9.5 years, 182,291 incident diabetes cases were identified. Multivariate analysis revealed a significantly higher diabetes risk in the MAFLD group compared to those in the Non-MAFLD group (HR = 6.148, 95 % CI, 6.084-6.212). Notably, diabetes incidence was highest in FLI ≥ 60 subgroup with BMI ≥ 23 and metabolic syndrome.
MAFLD is associated with a 6.1-fold increased diabetes risk in young adults, underscoring the urgent need for early intervention to mitigate this risk.
探讨代谢相关脂肪性肝病（MAFLD）对韩国年轻成年人 2 型糖尿病发病风险的影响。
数据来源于韩国国家健康保险服务-健康筛查队列，该队列包括 2009 年至 2012 年间接受健康检查的 20-39 岁成年人。根据是否存在 MAFLD 和非酒精性脂肪性肝病（NAFLD），以及是否同时存在这两种情况，将参与者进行分组。分组包括非 FLD、仅 NAFLD、仅 MAFLD 和同时存在两种 FLD。通过随访期间的理赔数据确定新发糖尿病病例。
在 6232656 名参与者中，有 676747 人（10.8%）患有 MAFLD。在中位随访 9.5 年期间，共发现 182291 例新发糖尿病病例。多变量分析显示，MAFLD 组的糖尿病发病风险明显高于非 MAFLD 组（HR=6.148，95%CI：6.084-6.212）。值得注意的是，在 BMI≥23 和代谢综合征的 FLI≥60 亚组中，糖尿病发病率最高。
MAFLD 使年轻人发生糖尿病的风险增加 6.1 倍，这突显了迫切需要早期干预以降低这种风险。
