Department of Midwifery and Women's Health, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan.
Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan.
Sci Rep. 2023 Mar 28;13(1):5041. doi: 10.1038/s41598-023-31949-2.
Infantile skin problems not only cause temporary pain and discomfort, but also have a long-term impact on health. Hence, the purpose of this cross-sectional study was to clarify the relationship between inflammatory cytokines and Malassezia fungal facial skin problems in infants. Ninety-six 1-month-old infants were examined. Facial skin problems and the presence of inflammatory cytokines in the forehead skin were assessed using the infant facial skin visual assessment tool (IFSAT) and the skin blotting method, respectively. Malassezia, a fungal commensal, was detected using forehead skin swabs, and its percentage in the total fungal population was analyzed. Infants with positive interleukin-8 signals were more likely to have severe facial skin problems (p = 0.006) and forehead papules (p = 0.043). No significant association between IFSAT scores and Malassezia was found, but infants with forehead dryness had a lower percentage of M. arunalokei in the total fungal population (p = 0.006). No significant association was observed between inflammatory cytokines and Malassezia in the study participants. Longitudinal studies on the development of facial skin problems in infants are warranted to investigate the involvement of interleukin-8 and devise preventive strategies in the future.
婴儿的皮肤问题不仅会造成暂时的疼痛和不适，还会对健康产生长期影响。因此，本横断面研究旨在阐明炎症细胞因子与婴儿马拉色菌面部皮肤问题之间的关系。检查了 96 名 1 个月大的婴儿。使用婴儿面部皮肤视觉评估工具（IFSAT）和皮肤擦拭法分别评估面部皮肤问题和额部皮肤中炎症细胞因子的存在。使用额部皮肤拭子检测真菌共生马拉色菌，并分析其在总真菌群中的比例。具有白细胞介素-8 信号阳性的婴儿更有可能出现严重的面部皮肤问题（p=0.006）和额部丘疹（p=0.043）。IFSAT 评分与马拉色菌之间无显著相关性，但额部干燥的婴儿总真菌群中 M. arunalokei 的比例较低（p=0.006）。研究参与者的炎症细胞因子与马拉色菌之间无显著相关性。需要对婴儿面部皮肤问题的发展进行纵向研究，以调查白细胞介素-8 的参与情况，并在未来制定预防策略。
