Tumor Biology, ICMR-National Institute of Pathology, New Delhi, India.
Department of Computer Science, Jamia Millia Islamia, New Delhi, India.
WIREs Mech Dis. 2023 May-Jun;15(3):e1596. doi: 10.1002/wsbm.1596. Epub 2023 Mar 28.
Cyclooxygenase-2 (COX-2) is a key aspect of the physiology and pathogenesis of various cancer types. Overexpression of this enzyme is responsible for the elevated prostaglandin production and characteristic feature of breast cancer. Inhibition of COX-2 derived prostanoids facilitates anti-inflammatory, analgesic, and antipyretic effects of non-steroid anti-inflammation drugs. The overexpression of COX-2 is associated with inflammation, pain, and fever. The present study provides the updated relevant literature describing the role of well-characterized isoforms of cyclooxygenase with particular emphasis on COX-2, mechanism of action, the effect of the drug, combinatorial drugs, and microarray-based differential expression analysis and network analysis. We have discussed the currently used combinatorial treatments and their challenges in breast cancer. This article is categorized under: Cancer > Computational Models Cancer > Molecular and Cellular Physiology.
环氧化酶-2（COX-2）是各种癌症类型的生理学和发病机制的关键方面。这种酶的过度表达导致前列腺素的产生增加，这是乳腺癌的特征。COX-2 衍生的前列腺素的抑制作用有助于非甾体抗炎药的抗炎、镇痛和解热作用。COX-2 的过度表达与炎症、疼痛和发烧有关。本研究提供了描述具有特征性同工型的环氧化酶作用的最新相关文献，特别强调 COX-2、作用机制、药物作用、组合药物以及基于微阵列的差异表达分析和网络分析。我们讨论了目前用于乳腺癌的联合治疗及其挑战。本文归类于：癌症 > 计算模型 癌症 > 分子和细胞生理学。
