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作为靶向芳香化酶和COX-2的潜在抗癌药物的迷人来源：综述。

L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An Overview.

作者信息

Gargano Adriana, Greco Ilario, Lupia Carmine, Alcaro Stefano, Ambrosio Francesca Alessandra

机构信息

Dipartimento di Scienze della Salute, Università degli Studi "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.

Associazione CRISEA-Centro di Ricerca e Servizi Avanzati per l'Innovazione Rurale, Loc. Condoleo, 88055 Belcastro, Italy.

出版信息

Molecules. 2025 Apr 12;30(8):1733. doi: 10.3390/molecules30081733.

DOI:10.3390/molecules30081733
PMID:40333668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12029578/
Abstract

Cancer is the second leading cause of death in the world, with scientific evidence indicating that the enzymes aromatase and cyclooxygenase 2 are upregulated in several types of cancer. Over the past 30 years, natural compounds have played a crucial role in cancer chemotherapy, and to date, many phytocompounds have been reported to interact with these enzymes, inhibiting their activity. Notably, several phytocompounds found in L., a medicinal plant native to the Mediterranean region and cultivated around the world, have shown the ability to interact with these enzymes. This review examines the role of the main compounds contained in . as potential anticancer agents acting on aromatase and cyclooxygenase-2.

摘要

癌症是全球第二大死因，科学证据表明，芳香化酶和环氧化酶2在多种癌症中上调。在过去30年里，天然化合物在癌症化疗中发挥了关键作用，迄今为止，已有许多植物化合物被报道可与这些酶相互作用，抑制其活性。值得注意的是，在地中海地区原产并在世界各地种植的药用植物罗勒中发现的几种植物化合物，已显示出与这些酶相互作用的能力。本综述探讨了罗勒中所含主要化合物作为作用于芳香化酶和环氧化酶-2的潜在抗癌剂的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/c2391bdbadd1/molecules-30-01733-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/45ee175a3826/molecules-30-01733-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/bbe70bb6daf9/molecules-30-01733-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/cbe28234760a/molecules-30-01733-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/03133473f57a/molecules-30-01733-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/5623db470921/molecules-30-01733-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/c2391bdbadd1/molecules-30-01733-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/45ee175a3826/molecules-30-01733-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/bbe70bb6daf9/molecules-30-01733-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/cbe28234760a/molecules-30-01733-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/03133473f57a/molecules-30-01733-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/5623db470921/molecules-30-01733-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61d4/12029578/c2391bdbadd1/molecules-30-01733-g006.jpg

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Chemical Profile of Essential Oils of Selected Lamiaceae Plants and In Vitro Activity for Varroosis Control in Honeybees .selected唇形科植物精油的化学特征及对蜜蜂蜂螨病的体外防治活性 。 （你原文中“selected Lamiaceae Plants”这里的“selected”应该有问题，推测是“selected Lamiaceae Plants”，我按此翻译了，若有误请指出）
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Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer.
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Eur J Med Chem. 2023 Dec 5;261:115866. doi: 10.1016/j.ejmech.2023.115866. Epub 2023 Oct 13.
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Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis.人胎盘芳香酶和类固醇硫酸酯酶的结构和功能，这两种酶是雌激素生物合成中的关键酶。
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