Mohammed Eihab Idris, Elmosaad Yousif Mohammed, Waggiallah Hisham Ali
Pak J Biol Sci. 2022 Nov;25(12):1094-1099. doi: 10.3923/pjbs.2022.1094.1099.
<b>Background and Objective:</b> The most common genetic disease in humans is hemoglobinopathies, also known as hemoglobin hereditary diseases. The purpose of this study was to look at the hemoglobinopathy patterns in anemic patients with a history of sickle cell disease in Saudi Arabia's Eastern Province. <b>Materials and Methods:</b> This prospective cross-sectional study was conducted on anemic patients attending the hospital with a strong family history of hemoglobinopathy and general signs and symptoms, as well as mild to moderate anemia crises. One hundred and ten people were chosen to participate in this study. The research was carried out between September, 2019 and October, 2020. <b>Results:</b> The sickle cell trait was the most common hemoglobinopathy in males (31.1%) and sickle cell trait+beta thalassemia minor was the most common in females (18%). The gender of patients and the distribution of hemoglobinopathy types were found to have a significant relationship (p-value of 0.001). <b>Conclusion:</b> A significant correlation was discovered between the gender of patients and the distribution of hemoglobinopathy types. More efforts must be made to raise the prevention of endogamy awareness among Saudis.
背景与目的：人类最常见的遗传病是血红蛋白病，也称为血红蛋白遗传性疾病。本研究的目的是观察沙特阿拉伯东部省份有镰状细胞病病史的贫血患者的血红蛋白病模式。材料与方法：这项前瞻性横断面研究是针对有血红蛋白病家族史且有一般体征和症状以及轻度至中度贫血危机的住院贫血患者进行的。选择了110人参与本研究。研究于2019年9月至2020年10月进行。结果：镰状细胞性状是男性中最常见的血红蛋白病（31.1%），镰状细胞性状+β地中海贫血轻型是女性中最常见的（18%）。发现患者性别与血红蛋白病类型分布之间存在显著关系（p值为0.001）。结论：发现患者性别与血红蛋白病类型分布之间存在显著相关性。必须做出更多努力来提高沙特人对近亲结婚预防的认识。
