Bouguerra Lucas, Dupraz Chrystelle, Plouzeau Chloé, Michaud Anthony, Broutin Lauranne, Cremniter Julie, Burucoa Christophe, Pichon Maxime
Université de Poitiers, Faculté de Médecine et Pharmacie, 86000 Poitiers, France.
CHU de Poitiers, Service d'oncologie et Hématologie Pédiatrique, 86021 Poitiers, France.
Antibiotics (Basel). 2023 Mar 6;12(3):528. doi: 10.3390/antibiotics12030528.
is a Gram-positive bacillus that has not been reported as pathogenic in pediatric patients. Herein, a case of catheter-associated bloodstream infection by in a 13-year-old immunocompromised child with febrile neutropenia induced for osteosarcoma is reported. The species was identified by Sanger sequencing of the 16s rRNA sequence of the bacterial strain and was compared phylogenetically with published sequences. As suggested in the literature, the presented strain was multi-susceptible, particularly to amoxicillin. The patient was treated with piperacillin/tazobactam for seven days in the context of a urinary co-infection, resulting in resolution of fever within 48 h and then relaunched with oral amoxicillin for 3 days (for a total of 10 days of antibiotic therapy). Phylogenetic analyses based on 16S rDNA demonstrated the complexity of the genus spp. but failed to demonstrate a direct benefit in predicting clinical outcome based on this single information.
是一种革兰氏阳性杆菌，在儿科患者中尚未被报道为致病性细菌。在此，报告了一例13岁免疫功能低下儿童因骨肉瘤诱发发热性中性粒细胞减少症，发生由该菌引起的导管相关血流感染的病例。通过对细菌菌株的16s rRNA序列进行桑格测序鉴定该菌种，并与已发表的序列进行系统发育比较。如文献中所提示的，所呈现的菌株对多种药物敏感，尤其是对阿莫西林敏感。该患者在合并泌尿系统感染的情况下接受哌拉西林/他唑巴坦治疗7天，48小时内发热消退，随后改用口服阿莫西林治疗3天（抗生素治疗共10天）。基于16S rDNA的系统发育分析证明了该菌属菌种的复杂性，但未能证明基于这一单一信息在预测临床结果方面有直接益处。
