Shiraishi N, Akiyama S, Kobayashi M, Kuwano M
Cancer Lett. 1986 Mar;30(3):251-9. doi: 10.1016/0304-3835(86)90049-2.
Chloroquine, a well-known lysosomotropic amine, partially reversed the resistance of multi-drug-resistant KB carcinoma cells to adriamycin, daunomycin, vincristine, vinblastine and actinomycin D. Other lysosomotropic amines, propranolol, atropine, amantadine and nicotine, also restored the sensitivity of multi-drug-resistant cells to the anticancer drugs. The increased rate of accumulation of [3H] daunomycin by chloroquine was more prominent in the resistant KB-ChR-24 cells than in the parental KB cells. Chloroquine inhibited the efflux of daunomycin from the resistant cells. Circumvention of multiple drug resistance in human KB carcinoma cells by the agents is discussed in relation to lysosomal function.
氯喹是一种著名的亲溶酶体胺，它能部分逆转多药耐药的KB癌细胞对阿霉素、柔红霉素、长春新碱、长春花碱和放线菌素D的耐药性。其他亲溶酶体胺，如普萘洛尔、阿托品、金刚烷胺和尼古丁，也能恢复多药耐药细胞对抗癌药物的敏感性。氯喹使[3H]柔红霉素在耐药的KB-ChR-24细胞中的积累速率增加，这在耐药细胞中比在亲代KB细胞中更为显著。氯喹抑制了柔红霉素从耐药细胞中的外流。本文结合溶酶体功能讨论了这些药物对人KB癌细胞多药耐药性的规避作用。
