Carlisi Melania, Lo Presti Rosalia, Mancuso Salvatrice, Siragusa Sergio, Caimi Gregorio
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.
Department of Psychology, Educational Science and Human Movement, University of Palermo, 90127 Palermo, Italy.
Biomedicines. 2023 Mar 21;11(3):964. doi: 10.3390/biomedicines11030964.
In this single center study, we retrospectively evaluated the calculated hemorheological profile in patients with a new diagnosis of multiple myeloma, with the aim to evaluate possible relationships with some prognostic predictors, such as ISS, albumin levels, beta2-microglobulin, red cell distribution width, and bone marrow plasma cell infiltration.
In a cohort of 190 patients, we examined the calculated blood viscosity using the de Simone formula, and the albumin/fibrinogen ratio as a surrogate of erythrocyte aggregation, and then we related these parameters to prognostic factors, using the Kruskal-Wallis and the Mann-Whitney tests, respectively.
From our analysis, it emerged that the evaluated hemorheological pattern differed in the three isotypes of multiple myeloma, and the whole blood viscosity was higher in IgA and IgG isotypes with respect to the light chain multiple myeloma ( < 0.001). Moreover, we observed that, as the ISS stage progressed, the albumin/fibrinogen ratio was reduced, and the same hemorheological trend was traced in subgroups with lower albumin levels, higher beta2-microglobulin and red cell distribution width RDW values, and in the presence of a greater bone marrow plasma cell infiltrate.
Through the changes in blood viscosity in relation to different prognostic factors, this analysis might underline the role of the hemorheological pattern in multiple myeloma.
在这项单中心研究中，我们回顾性评估了新诊断的多发性骨髓瘤患者的计算血液流变学特征，旨在评估其与一些预后预测指标的可能关系，如国际分期系统（ISS）、白蛋白水平、β2-微球蛋白、红细胞分布宽度和骨髓浆细胞浸润情况。
在一组190例患者中，我们使用德西蒙公式检测计算得出的血液粘度，并检测白蛋白/纤维蛋白原比值作为红细胞聚集的替代指标，然后分别使用克鲁斯卡尔-沃利斯检验和曼-惠特尼检验将这些参数与预后因素相关联。
通过我们的分析发现，多发性骨髓瘤的三种亚型的评估血液流变学模式有所不同，IgA和IgG亚型的全血粘度高于轻链型多发性骨髓瘤（P<0.001）。此外，我们观察到，随着ISS分期进展，白蛋白/纤维蛋白原比值降低，在白蛋白水平较低、β2-微球蛋白和红细胞分布宽度（RDW）值较高的亚组以及骨髓浆细胞浸润较多的情况下，也呈现出相同的血液流变学趋势。
通过与不同预后因素相关的血液粘度变化，该分析可能凸显了血液流变学模式在多发性骨髓瘤中的作用。
